2025.10-至今：中国农业大学，教授

2020.11-2025.9：中国农业大学，优秀人才引进，副教授

2018.7-2020.10：中国农业大学，博士后

2013.9-2018.6：中国农业大学，生物化学与分子生物学，理学博士

2009.6-2013.6：河北农业大学，生物工程，工学学士

学术任职：

中国民族卫生协会临床医学分会2020-至今 理事

肠道稳态和肠道疾病的机制研究

肠道干细胞及其微环境的功能与调控机制研究

1. 国家自然科学基金面上项目：探究Msi1+Lgr5neg/low肠道干细胞抵抗辐射并驱动肠上皮再生的新机制，2023-2026年，主持

2. 国家重点研发计划课题：增龄及老年消化疾病的消化道黏膜上皮及微环境变化特征研究，2022-2025年，主持

3. 国家重点研发计划子课题：幼龄动物消化道免疫功能的成熟机制及调控，2022-2027年，主持

4. 国家自然科学基金青年科学基金项目：间充质Islr在结肠炎中调控上皮再生的功能及机制究，2021-2023年，主持

5. 博士后创新人才计划：探究microRNA在小肠干细胞和肠道健康中的功能和调控机制，2018-2020年，主持

6. 博士后基金面上项目：探究Numb和Numbl基因在乳腺癌转移过程中的作用机制，2019-2020年，主持

1.     Shiyang Wang^#, Xi Wu^#, Wenxin Bi, Jiuzhi Xu, Liyuan Hou, Guilin Li, Yuwei Pan, Hanfu Zhang, Mengzhen Li, Sujuan Du, Mingxin Zhang, Di Liu, Shuiling Jin, Xiaojing Shi, Yuhua Tian, Jianwei Shuai, MaksimV. Plikus, Moshi Song, Zhaocai Zhou, Lu Yu*, Cong Lv* and Zhengquan Yu*. ROS-induced cytosolic release of mitochondrial PGAM5 promotes colorectal cancer progression by interacting withMST3. Nature Communications 2025 16(1):1406. doi: 10.1038/s41467-025-56444-2.

2.     Xi Wu^#; Shiyang Wang^#; Yuwei Pan; Mengzhen Li; Manyu Song; Hanfu Zhang; Min Deng; Xu Yang; Jiuzhi Xu; Shuo Zhang; Jinhua Zhang; Fengchao Wang; Maksim V. Plikus; Cong Lv*; Lu Yu* and Zhengquan Yu*. m6A Reader PRRC2A Promotes Colorectal Cancer Progression via CK1𝝐-Mediated Activation of WNT and YAP Signaling Pathways. Advance Science 2025 12(3):e2406935. doi: 10.1002/advs.202406935.

3.     Xin Huang^#; Xu Yang^#; Mingxin Zhang^#; Tong Li; Kongdi Zhu; Yulan Dong; Xingen Lei; Zhengquan Yu; Cong Lv* and Jiaqiang Huang*; SELENOI Functions as a Key Modulator of Ferroptosis Pathway in Colitis and Colorectal Cancer, Advanced Science 2024, 11(28):e2404073.

4.     Xu Yang^#; Guilin Li^#; Pengbo Lou; Mingxin Zhang; Kai Yao; Jintao Xiao; Yiqian Chen; Jiuzhi Xu; Shengyuan Tian; Min Deng; Yuwei Pan; Mengzhen Li; Xi Wu; Ruiqi Liu; Xiaojing Shi; Yuhua Tian; Lu Yu; Hao Ke; Baowei Jiao; Yingzi Cong; Maksim V. Plikus; Xiaowei Liu*; Zhengquan Yu* and Cong Lv*; Excessive nucleic acid R-loops induce mitochondria-dependent epithelial cell necroptosis and drive spontaneous intestinal inflammation, PNAS 2023,121(1):e2307395120. doi: 10.1073/pnas.2307395120.

5.     Min Deng^#; Christian F. Guerrero-Juarez^#; Xiaole Sheng; Jiuzhi Xu; Xi Wu; Kai Yao; Mengzhen Li; Xu Yang; Guilin Li; Jintao Xiao; Xiaowei Liu; Kaichun Wu; Fazheng Ren; Qing Nie; Maksim V. Plikus; Zhengquan Yu* and Cong Lv*; Lepr⁺ mesenchymal cells sense diet to modulate intestinal stem/progenitor cells via Leptin-Igf1 axis, Cell Research 2022, 32, 670-686.

6.     Xu Yang^#; Guilin Li^#; Yuhua Tian; Xin Wang; Jiuzhi Xu; Ruiqi Liu; Min Deng; Chunlei Shao; Yuwei Pan; Xi Wu; Mengzhen Li; Chaowei Zhang; Rui Liu; Jun Qin; Chen Zhang; Zhanju Liu; Xin Wu; Maksim V. Plikus; Christopher J. Lengner; Zongheng Zheng*; Cong Lv* and Zhengquan Yu*; Identifying the E2F3-MEX3A-KLF4 signaling axis that sustains cancer cells in undifferentiated and proliferative state, Theranostics 2022, 12(16): 6865-6882.

7.     Ruiqi Liu^#; Huan Hu; Melissa McNeil; Jiuzhi Xu; Xueyun Bi; Pengbo Lou; Christian F. Guerrero-Juarez; Xing Dai; Maksim V. Plikus; Jianwei Shuai*; Zhengquan Yu*; Cong Lv*; Dormant Nfatc1 reporter-marked basal stem/progenitor cells contribute to mammary lobuloalveoli formation, iScience 2022, 25(3) :103982.

8.     Jianyang Wang^#; Linkuo Shang^#; Jiahui Zhang; Zhengquan Yu; Jiaqiang Huang*; Jing Jin*; Cong Lv*; Nfatc1⁺ colonic stem cells contribute to regeneration upon colitis, Journal of Gastroenterology and Hepatology, 2022, 37(4):734-740.

9.     Min Deng; Xi Wu; Xiaoyue Duan; Jiuzhi Xu; Xu Yang; Xiaole Sheng; Pengbo Lou; Chunlei Shao; Cong Lv* and Zhengquan Yu *; Lactobacillus paracasei L9 improves colitis by expanding butyrate-producing bacteria that inhibit the IL-6/STAT3 signaling pathway; Food & Function, 2021, 12(21):10700-10713.

10.  Cong Lv^#; Fengyin Li^#; Xiang Li^#; Yuhua Tian^#; Yue Zhang; Xiaole Sheng; Yongli Song; Qingyong Meng; Shukai Yuan; Liming Luan; Thomas Andl; Xu Feng; Baowei Jiao; Mingang Xu; Maksim V Plikus; Xing Dai; Christopher Lengner; Wei Cui; Fazheng Ren; Jianwei Shuai; Sarah E Millar; Zhengquan Yu*; MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists, Nature Communications, 2017, 8(1).

11.  Xiaole Sheng^#; Ziguang Lin^#; Cong Lv^#; Chunlei Shao; Xueyun Bi; Min Deng; Jiuzhi Xu; Christian F Guerrero-Juarez; Mengzhen Li; Xi Wu; Ran Zhao; Xu Yang; Guilin Li; Xiaowei Liu; Qingyu Wang; Qing Nie; Wei Cui; Shan Gao; Hongquan Zhang; Zhihua Liu; Yingzi Cong; Maksim V Plikus; Christopher J Lengner; Bogi Andersen; Fazheng Ren*; Zhengquan Yu*; Cycling Stem Cells Are Radioresistant and Regenerate the Intestine, Cell Reports, 2020, 32(4):107952.

12.  Yuhua Tian^#; Xianghui Ma^#; Cong Lv^#; Xiaole Sheng; Xiang Li; Ran Zhao; Yongli Song; Thomas Andl; Maksim V Plikus; Jinyue Sun; Fazheng Ren; Jianwei Shuai; Christopher J Lengner; Wei Cui; Zhengquan Yu*; Stress responsive miR-31 is a major modulator of mouse intestinal stem cells during regeneration and tumorigenesis, eLife, 2017, 6(e29538).