2012-至今：中国农业大学理学院应用化学系，教授

2010-2011：中国农业大学理学院应用化学系，副教授

2009-2010：美国加州大学洛杉矶分校, 访问学者

2008-2009：美国伊利诺伊大学厄本那-香槟分校, Research Associate

2006-2008：美国加州大学洛杉矶分校, 博士后

2004-2006：德国马普所(Muelheim), Research Associate

2002-2004：中国科学院上海有机化学研究所, 博士后

1997-2002：中国农业大学应用化学系, 理学博士

1993-1997：中国农业大学应用化学系, 理学学士

1. 研究金属和有机小分子催化的环加成及环化反应，特别是基于1,3-偶极子的高效、高选择性环加成反应，发展高效的选择性合成方法，并利用手性金属催化剂和手性有机小分子催化剂发展高效和高选择性的不对称合成新方法，研究这些方法在杂环分子及复杂生物活性分子合成中的应用。

2. 合成具有重要生物活性的杂环化合物及天然产物，用于杀虫剂、除草剂、杀菌剂及植物生长调节剂等的研究，开展新农药创制工作。

3. 研究农药的创新合成工艺。

1. Biming Mao, Honglei Liu, Zhengyang Yan, Yi Xu, Jiaqing Xu, Wei Wang, Yongjun Wu, Hongchao Guo,* “Palladium-Catalyzed Asymmetric [4+2] Cycloaddition of 2-Methylidenetrimethylene Carbonate with Alkenes: Access to Chiral Tetrahydropyran-Fused Spirocyclic Scaffolds”, Angew. Chem. Int. Ed. 2020, 59, DOI: 10.1002/anie.202002765.

2. Yunyao Zhu, Jiangjiexing Wu, Lijun Han, Xiaoyu Wang, Wei Li, Hongchao Guo,* Hui Wei,* “Nanozyme Sensor Arrays Based on Heteroatom-Doped Graphene for Detecting Pesticides”. Anal. Chem. 2020, 92,7444−7452.

3. Wangyu Shi, Biming Mao, Jiaqing Xu, Qijun Wang, Wei Wang, Yongjun Wu, Xuefeng Li, Hongchao Guo,* Phosphine-Catalyzed Cascade Michael Addition/[4+2] Cycloaddition Reaction of Allenoates and 2-Arylidene-1,3-indanediones, Org. Lett. 2020, 22, 2675−2680.

4. Biming Mao, Junya Zhang, Yi Xu, Zhengyang Yan, Wei Wang, Yongjun Wu, Changqing Sun, Bing Zheng, and Hongchao Guo,* “Palladium-catalyzed [3+2] annulation of allenyl carbinol acetates with C,N-cyclic azomethine imines”, Chem. Commun. 2019, 55, 12841−12844.

5. Chang Wang, Yuehua Chen, Jingyu Li, Leijie Zhou, Bo Wang, Yumei Xiao, and Hongchao Guo,* “Phosphine-Catalyzed Asymmetric Cycloaddition Reaction of Diazenes: Enantioselective Synthesis of Chiral Dihydropyrazoles”, Org. Lett. 2019, 21, 7519−7523.

6. Leijie Zhou, Yuan Zeng, Xing Gao, Qijun Wang, Chang Wang, Bo Wang, Wei Wang, Yongjun Wu, Bing Zheng,* and Hongchao Guo,* “A chiral squaramide-catalyzed asymmetric dearomative tandem annulation reaction through a kinetic resolution of MBH alcohols: highly enantioselective synthesis of three-dimensional heterocyclic compounds”, Chem. Commun. 2019, 55, 10464−10467.

7. Leijie Zhou, Chunhao Yuan, Yuan Zeng, Qijun Wang, Chang Wang, Min Liu, Wei Wang, Yongjun Wu, Bing Zheng,* and Hongchao Guo,* “Direct Activation of Unmodified Morita-Baylis-Hillman Alcohols through Phosphine Catalysis for Rapid Construction of Three-Dimensional Heterocyclic Compounds”, Org. Lett. 2019, 21, 4882−4886.

8. Biming Mao, Yi Xu, Yuehua Chen, Jipan Dong, Junya Zhang, Kejia Gu, Bing Zheng and Hongchao Guo,* “Palladium-Catalyzed Asymmetric Tandem [3+2] Cycloaddition/Allylation Reaction of Methylene-Trimethylenemethane: Access to Chiral Tricyclic Dinitrogen-Fused Heterocycles”, Org. Lett. 2019, 21, 4424−4427.

9. Xing Gao, Miaoren Xia, Chunhao Yuan, Leijie Zhou, Wei Sun, Cheng Li, Bo Wu, Dongyu Zhu, Cheng Zhang, Bing Zheng, Dongqi Wang, Hongchao Guo,* “Enantioselective Synthesis of Chiral Medium-Sized Cyclic Compounds via Tandem Cycloaddition/Cope Rearrangement Strategy”, ACS Catal. 2019, 9, 1645−1654.

10. Wangyu Shi, Leijie Zhou, Biming Mao, Qijun Wang, Chang Wang, Cheng Zhang, Xuefeng Li, Yumei Xiao,* and Hongchao Guo,* “Phosphine-Catalyzed [3+2] Annulation of β-Sulfonamido-Substituted Enones with Sulfamate-Derived Cyclic Imines”, J. Org. Chem. 2019, 84, 679−686.

11. Hongchao Guo,* Yi Chiao Fan, Zhanhu Sun, Yang Wu, and Ohyun Kwon,* “Phosphine Organocatalysis”, Chem. Rev. 2018, 118, 10049−10293.

12. Leijie Zhou, Chang Wang, Chunhao Yuan, Honglei Liu, Cheng Zhang, and Hongchao Guo,* “Phosphine-Catalyzed [3+2] Annulation of 2-Hydroxy-1,4-Naphthaquinones and Allenoate: An Allene-Alkene [3+2] Annulation Mechanism Involving Consecutive γ-Addition–Aldol Reaction”, Org. Lett. 2018, 20, 6591−6595.

13. Feng Jiang, Xinping Feng, Rou Wang, Xing Gao, Hao Jia, Yumei Xiao, Cheng Zhang,* and Hongchao Guo,* “Asymmetric [3+3] Annulation of Copper−Allenylidenes with Pyrazolones: Synthesis of Chiral 1,4-Dihydropyrano[2,3-c]pyrazoles”, Org. Lett. 2018, 20, 5278–5281.

14. Zhenzhen Gao, Chang Wang, LeijieZhou, Chunhao Yuan, Yumei Xiao, Hongchao Guo,* “Phosphine-Catalyzed [8+2]-Annulation of Heptafulvenes with Allenoates and Its Asymmetric Variant: Construction of Bicyclo[5.3.0]decane Scaffold”, Org. Lett. 2018, 20, 4302–4305.

15. Hao Jia, Zhenyan Guo, Honglei Liu, Biming Mao, Xueyan Shi,* Hongchao Guo,* “Tandem Nucleophilic Addition–Cycloaddition of Arynes with α-Iminoesters: Two Concurrent Pathways to Imidazolidines”, Chem. Commun. 2018, 54, 7050–7053.

16. Honglei Liu, Hao Jia, Wangyu Shi, Chang Wang, Cheng Zhang, Hongchao Guo,* “Nickel (II)-Catalyzed [8+3] Cycloaddition of 2-Aryl-N-tosyl-aziridines with Tropone”, Org. Lett. 2018, 20, 3570–3573.

17. Zhenyan Guo, Hao Jia, Honglei Liu, Qijun Wang, Jiaxing Huang, Hongchao Guo,* “A [4+3] Annulation Reaction of aza-o-Quinone Methides with Arylcarbohydrazonoyl Chlorides for Synthesis of 2,3-Dihydro-1H-benzo[e][1,2,4]triazepines”, Org. Lett. 2018, 20, 2939–2943.

18. Chang Wang, Yan Li, Yang Wu, Qijun Wang, Wangyu Shi, Chunhao Yuan, Leijie Zhou, Yumei Xiao, Hongchao Guo,* “Enantioselective Construction of Tetrahydroquinazoline Motifs via Palladium-Catalyzed [4+2] Cycloaddition of Vinyl Benzoxazinones with Sulfamate-Derived Cyclic Imines”, Org. Lett. 2018, 20, 2880–2883.

19. Chunhao Yuan, Yang Wu, Dongqi Wang, Zhenhua Zhang, Chang Wang, Leijie Zhou, Cheng Zhang, Baoan Song, Hongchao Guo,* “Formal [5+3] Cycloaddition of Zwitterionic Allylpalladium Intermediates with Azomethine Imines for Construction of N,O-Containing Eight-Membered Heterocycles”, Adv. Synth. Catal. 2018, 360, 652–658.

20. Leijie Zhou, Chunhao Yuan, Yuan Zeng, Honglei Liu, Chang Wang, Xing Gao, Qijun Wang, Cheng Zhang, Hongchao Guo,* “Phosphine-Catalyzed [5+1] Annulation of δ-Sulfonamido-Substituted Enones with N-Sulfonylimines: A Facile Synthesis of Tetrahydropyridines”, Chem. Sci. 2018, 9, 1831–1835.