2021.03-至今：中国农业大学，副教授（优秀人才引进）

2018.07-2021.03：中国农业大学，北京食品营养与人类健康高精尖创新中心， 博士后

2013.09-2018.06：中国农业大学，工学博士

2009.09-2013.07：中国农业大学，工学学士

1. 营养素的功能活性及作用机制

2. 功能食品的开发与功能评价

3. 食源性危害因子的作用机理

1. 校企合作项目“乳源蛋白及组合物肠道免疫功效研究“，主持

2. 揭榜挂帅项目“益生菌产业化关键技术研究与应用“，主持

3. 国家自然科学重点基金-直接超高温灭菌乳蛋白复合体的结构表征及“老化凝胶”形成机制，课题骨干

4. 中国工程院一般战略咨询项目“食品安全营养健康学科建设战略研究”，课题骨干

5. 中国工程院重大战略咨询项目“食品营养与健康战略研究”，课题骨干

一、发表文章

①    Yixuan Li, Jiaqiang Huang, Jingxuan Wang, Mengjuan Ma, Yao Lu, Ran Wang, Huiyuan Guo Lactoferrin is a potential activator of the vitamin D receptor in its regulation of osteogenic activities in C57BL/6J mice and MC3T3-E1 cells Journal of Nutrition, 2021

②    Yixuan Li, Jingxuan Wang, Fazheng Ren, Wei Zhang, Hao Zhang, Liang Zhao, Ming Zhang, Wei Cui, Xiaobin Wang, and Huiyuan Guo* Lactoferrin Promotes Osteogenesis through TGF-β Receptor II Binding in Osteoblasts and Activation of Canonical TGF-β Signaling in MC3T3-E1 Cells and C57BL/6J Mice. Journal of Nutrition, 2018, 148(8), 1285-1292

③    Yixuan Li, Wei Zhang, Fazheng Ren, and Huiyuan Guo* Activation of TGF-_ Canonical and Noncanonical Signaling in Bovine Lactoferrin-Induced Osteogenic Activity of C3H10T1/2 Mesenchymal Stem Cells. International Journal of Molecular Science, 2019, 20,2880

④    Chenyuan Wang, Ming Zhang, Huiyuan Guo, Jingyu Yan, Lingli Chen, Wendi Teng, Fazheng Ren, Yiran Li, Xifan Wang, Jie Luo, and Yixuan Li* Human Milk Oligosaccharides Activate Epidermal Growth Factor Receptor and Protect Against Hypoxia-Induced Injuries in the Mouse Intestinal Epithelium and Caco2 Cells. Journal of Nutrition, 2019, 10.1093

⑤    Ning Liu, Gang Feng, Xiaoying Zhang, Qingjuan Hu, Shiqiang Sun, Jiaqi Sun, Yanan Sun, Ran Wang, Yan Zhang, Pengjie Wang and Yixuan Li* The Functional Role of Lactoferrin in Intestine Mucosal Immune System and Inflammatory Bowel Disease. Frontiers in Nutrition, 2021, 8, 759507

⑥    Guoping Zhao, Xiaoyu Wang, Jinwang Li, Ran Wang, Fazheng Ren, Guofang Pang, Yixuan Li*. Imidacloprid increases intestinal permeability by disrupting tight junctions. 2021, 222, 112476

⑦    Guoping Zhao, Jinwang Li, Fangwei Yang, Xiaoyu Wang, Fazheng Ren, Guofang Pang, Yixuan Li*. Nitrogen contaminants damage on intestinal epithelial tight junctions: a review. Environmental Chemistry Letters, 2021, 19 (6), 4549-4561

⑧    Haina Gao, Fazheng Ren, Pengcheng Wen, Xiaoli Xie, Ran Wang, Zhennai Yang*, Yixuan Li*. Yak milk-derived exosomal miRNA regulate intestinal epithelial cells on proliferation in hypoxic environment. Journal of Dairy Science, 2021, 104(2), 1291-1303

⑨    Jinwang Li, Bing Fang, Fazheng Rena, Hanzhu Xing, Guoping Zhao, Xuefeng Yin, Guofang Pang, Yixuan Li*. TCP structure intensified the chlorpyrifos-induced decrease in testosterone synthesis via LH-LHR-PKA-CREB-Star pathway. Science of the Total Environment, 2020, 10.1016

⑩    Fang-Wei Yang, Guo-Ping Zhao, Fa-Zheng Ren, Guo-Fang Pang*, Yi-Xuan Li*. Assessment of the endocrine-disrupting effects of diethyl phosphate, a nonspecific metabolite of organophosphorus pesticides, by in vivo and in silico approaches. Environment International, 2019, 135

⑪     Ran Wang*, Jian Sun , Guihua Li, Ming Zhang, Tianjiao Niu, Xiaohong Kang, Hongfeng Zhao, Jianguo Chen, Erna Sun, Yixuan Li*. Effect of Bifidobacterium animalis subsp. lactis MN-Gup on constipation and the composition of gut microbiota. Beneficial Microbes, 2020: 1-12.

⑫     Yanxiong Huo, Xuhong Lu, Xiaoyu Wang, Xifan Wang, Lingli Chen, Huiyuan Guo, Ming Zhang*, Yixuan Li*. Bifidobacterium animalis subsp. Lactis A6 Alleviates Obesity Associated with Promoting Mitochondrial Biogenesis and Function of Adipose Tissue in Mice. Molecules, 2020. 25(7).

⑬     Jingxuan Wang, Yixuan Li, Liang Zhao, Fazheng Ren, Huiyuan Guo*. Lactoferrin stimulates the expression of vitamin D receptor in vitamin D deficient mice. Journal of Functional Foods. 2019: 48-56.

⑭     李依璇，罗洁，任发政，郭慧媛. 我国乳制品工业的发展历程. 中国奶牛，2019.10

⑮     张一帆，逄金柱，米丽娟，李依璇*. 添加α-乳白蛋白和色氨酸的婴儿配方奶粉对新生大鼠脑发育的影响, 中国食品学报，2022.3

二、授权专利

①     牦牛乳乳清蛋白源ACE抑制肽及其制备方法，ZL 201510077783.8，任发政、赵亮、罗洁、郭慧媛、李依璇、田劢、崔娜

②     一种益生菌组合物及其在制备共病便秘抑郁症药物中的应用，ZL 202111145201.7，任发政，陈善斌，王然，李依璇，任怡镁