2005-2009     武汉大学生命科学学院，本科

2009-2014     中国科学院营养科学研究所/华东理工大学， 硕博连读

2014-2016     浙江大学转化医学研究院，助理研究员

2016-2020     中国农业大学食品营养与人类健康高精尖创新中心，岗位科学家

2020-2022     中国农业大学理学院，博士后

2022  至今     中国农业大学营养与健康系，副教授

主要研究方向为微量营养素稳态与代谢性疾病。通过人群流行病学及分子生物学等手段，发现微量营养素的稳态调控机制及其失衡对常见慢病的影响，开发具有针对性的营养干预策略。

2024.1-2027.12，国家自然基金面上项目，项目负责人

2023.12-2027.12，国家重点研发计划，子课题任务负责人

2016.1-2018.12，国家自然基金青年科学基金，项目负责人。

1. Xu T,^# Zhang X,^# Zhao W, Shi J, Wan S, Zhang Y, Hao Y, Sun M, He J, Jiang L, Wang H, Gao H*, Luo J*, Luo Y*, An P*. Foxo1 is an iron-responsive transcriptional factor regulating systemic iron homeostasis. Blood, 2024; 144, 1314–1328. (* Corresponding author) 封面论文

Editorial: Yien, Y.Y. What does the FOX(O) say? High iron: hepcidin! Blood 2024; 144, 1243–1245.

2. Zhao W, ^# Chen J, ^# Xia Y, ^# Wei Z, Wan S, Guo H, Hao Y, Jiang W, Zhang H, Ren F*, An P*, Luo Y*, Luo J*. Temporal-specific single-cell atlas of human type A aortic dissection reveals immune cell dynamics and therapeutic targets. Science Bulletin, 2024. Doi: 10.1016/j.scib.2024.07.001 (* Corresponding author)

3. Zhou S,^# Cheng F,^# He J, Xu T, Zhang X, Wan S, Qi J, He J, Chen F, Luo J,* Luo Y,* An P*. Effects of high-quality protein supplementation on cardiovascular risk factors in individuals with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials. Clinical Nutrition 2023; 43, 1740–1750. (* Corresponding author)

4. An P, Yang A., Li J, Luo Y. Micronutrients and Metabolic Diseases. Frontiers Research Topics. (2024) doi:10.3389/978-2-8325-4671-0. ISSN:1664-8714.

5. Liu S, An P. Untangling the uncertainty in B vitamins for stroke prevention: folic acid fortification, dosage, and their interaction? The American Journal of Clinical Nutrition 119, 593–594 (2024).

6. Xu T, Wan S, Shi J, Xu TC, Wang L, Guan Y, Luo J, Luo Y, Sun M,^* An P,^* He J ^*. Antioxidant Minerals Modified the Association between Iron and Type 2 Diabetes in a Chinese Population. Nutrients 16, 335 (2024). (* Corresponding author)

7. Luo Y, ^# Luo J, ^# An P, ^# Zhao Y,^# Zhao W,^# Fang Z, Xia Y, Zhu L, Xu T, Zhang Xu, Zhou S, Yang M, Li J, Zhu J, Liu Y, Li H, Gong M, Liu Y, Han J, Guo H,^# Zhang H,^* Jiang W,^* Ren F^*. The AP-1 complex governs a vascular degenerative transcriptional program in smooth muscle cells to trigger aortic dissection and rupture. European Heart Journal (2023). (# Co-first author)

- Editorial: Miteva, K. On target inhibition of vascular smooth muscle cell phenotypic transition underpins TNF–OXPHOS–AP-1 as a promising avenue for anti-remodelling interventions in aortic dissection and rupture. European Heart Journal 45, 306–308 (2023)..

8. Wan S, He J,^* Simoes EJ, Mechanick JI, Wu WC, An P, Liu S. Chromium supplementation to reduce cardiometabolic risk factors. JACC Advances, 2, 100729 (2023).

9. Wang X, ^# Ji Y, ^# Qi J, Zhou S, Wan S, Fan C, Gu Z, An P, ^* Luo Y, ^* Luo J^*. Mitochondrial carrier 1 (MTCH1) governs ferroptosis by triggering the FoxO1-GPX4 axis-mediated retrograde signaling in cervical cancer cells. Cell Death & Disease, 14, 508 (2023). (* Corresponding author)

10. Li N, ^# Wu B,^# Wang J, Yan Y, An P, Li Y, Li Y, Hou Y, Qing X, Niu L, Ding X, Xie Z, Zhang M, Guo X, Chen X, Cai T, Luo J, Wang F, Yang F*. Differential proteomic patterns of plasma extracellular vesicles show potential to discriminate β-thalassemia subtypes. iScience 26, 106048 (2023).

11. An P,^# Wan S,^# Luo Y, Luo J, Zhang X, Zhou S, Xu T, He J, Mechanick JI, Wu WC, Ren F,^* Liu S^*. Micronutrient Supplementation to Reduce Cardiovascular Risk. Journal of the American College of Cardiology 80, 2269–2285 (2022). (# Co-first author)

- Editorial: Gormaz JG, Carrasco R. Antioxidant Supplementation in Cardiovascular Prevention: New Challenges in the Face of New Evidence. J Am Coll Cardiol 80, 2286–2288 (2022).

12. He J,^# Chen F,^# Wan S, Luo Y, Luo J, He S, Zhou D,^* An P,^* Zeng P ^*. Association of serum antioxidant minerals and type 2 diabetes mellitus in Chinese urban residents. Antioxidants 12, 62 (2022). (* Corresponding author)

13. Li N, ^# An P, ^# Wang J, Zhang T, Qing X, Wu B, Sun L, Ding X, Niu L, Xie Z, Zhang M, Guo X, Chen X, Cai T, Luo J, Wang F^*, Yang F^*. Plasma proteome profiling combined with clinical and genetic features reveals the pathophysiological characteristics of β-thalassemia. iScience, 25, 104091 (2022). (# Co-first author)

14. Zhao X,^# Zhang X,^# Xu T, Luo J,^* Luo Y,^* An P^*. Comparative effects between oral lactoferrin and ferrous sulfate supplementation on iron-deficiency anemia: a comprehensive review and meta-analysis of clinical trials. Nutrients, 14, 543 (2022). (* Corresponding author)

15. Zhang J, Liu Z, Chen R, Ma Q, Lyu Q, Fu S, He Y, Xiao Z, Luo Z, Luo J, Wang X, Liu X, An P,^* Sun W^*. A MALDI-TOF mass spectrometry-based haemoglobin chain quantification method for rapid screen of thalassaemia. Annals of Medicine, 54, 293–301 (2022). (* Corresponding author)

16. Xu T, Zhang X, Liu Y, Wang H, Luo J,^* Luo Y,^* An P^*. Effects of dietary polyphenol supplementation on iron status and erythropoiesis: a systematic review and meta-analysis of randomized controlled trials. The American Journal of Clinical Nutrition, 114, 780–793 (2021). (* Corresponding author)

17. Fang X, Cai Z, Wang H, Han D, Cheng Q, Zhang P, Gao F, Yu Y, Song Z, Wu Q, An P, Huang S, Pan J, Chen H, Chen J, Linkermann A, Min J,^* Wang F^*. Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis. Circulation Research 127, 486–501 (2020).

18. Yang L,^# Wang H,^# Yang X, Wu Q, An P, Jin X, Liu W, Huang X, Li Y, Yan S, Shen S, Liang T,^* Min J,^* Wang F^*. Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms. Signal Transduction and Targeted Therapy, 5, 138 (2020).

19. Jiang Y,^# Li C,^# Wu Q,^# An P, Huang L, Wang J, Chen C, Chen X, Zhang F, Ma L, Liu S, He H, Xie S, Sun Y, Liu H, Zhang Y, Tao Y, Liu Z, Sun X, Hu Y, Wang Q, Ye D, Zhang J, Zou S, Wang Y, Wei G, Liu Y, Shi Y, Chin Y, Hao Y, Wang F,^* Zhang X^*. Nature Communications, 10, 2935 (2019).

20. Guo S,^# Jiang S,^# Epperla N, Ma Y, Maadooliat M, Ye Z, Olson B, Wang M, Kitchner T, Joyce J, An P, Wang F, Strenn R, Mazza JJ, Meece JK, Wu W, Jin L, Smith JA, Wang J,^* Schrodi SJ^*. A gene-based recessive diplotype exome scan discovers FGF6, a novel hepcidin-regulating iron-metabolism gene. Blood, 133, 1888–1898 (2019).

21. Jiang L,^# Wang K,^# Lo K,^# Zhong Y, Yang A, Fang X, Akezhuoli H, Song Z, Chen L, An P, Xu M., Min J,^* Wang F ^*. Sex-specific association of circulating ferritin level and risk of type 2 diabetes: a dose-response meta-analysis of prospective studies. The Journal of Clinical Endocrinology & Metabolism, 104, 4539–4551 (2019).

22. An P,^# Wang H,^# Wu Q, Wang, J, Xia Z, He X, Wang X, Chen Y, Min J,^* Wang F^*. Smad7 deficiency decreases iron and haemoglobin through hepcidin up-regulation by multilayer compensatory mechanisms. Journal of Cellular and Molecular Medicine, 22, 3035–3044 (2017).(# Co-first author)

23. Wang H, An P, Xie E, Wu Q, Fang X, Gao H, Zhang Z, Li Y, Wang X, Zhang J, Li G, Yang L, Liu W, Min J,^* Wang F^*. Characterization of ferroptosis in murine models of hemochromatosis. Hepatology, 66, 449–465 (2017).

24. An P,^# Jiang L,^# Guan Y, Wang H, Wang J, Tian Y, Yang W, Shi Y, Xue J, Min J, Wang F^*. Identification of hereditary hemochromatosis pedigrees and a novel SLC40A1 mutation in Chinese population. Blood Cells, Molecules, and Diseases, 63, 34–36 (2017). (# Co-first author)

25. Bao WD, Fan Y, Deng YZ, Long LY, Wang J, Guan DX, Qian ZY, An P, Feng YY, He ZY, Wang XF, Koeffler HP, Hu R, Wang J, Wang X, Wang F, Li JJ, Xie D^*. Iron overload in hereditary tyrosinemia type 1 induces liver injury through the Sp1/Tfr2/hepcidin axis. Journal of Hepatology, 65, 137–145 (2016).

26. Mu M, An P, Wu Q, Shen X, Shao D, Wang H, Zhang Y, Zhang S, Yao H, Min J, Wang F^*. The dietary flavonoid myricetin regulates iron homeostasis by suppressing hepcidin expression. The Journal of Nutritional Biochemistry, 30, 53–61 (2016).

27. Fang X, Wang H, An P, Min J, Wang F^*. Cardiomyocyte-specific deletion of ferroportin using MCK-Cre has no apparent effect on cardiac iron homeostasis. International Journal of Cardiology, 201, 90–92 (2015).

28. Fang X, An P, Wang H, Wang X, Shen X, Li X, Min J, Liu S, Wang, F. Dietary intake of heme iron and risk of cardiovascular disease: A dose–response meta-analysis of prospective cohort studies. Nutrition, Metabolism and Cardiovascular Diseases, 25, 24–35 (2014).

29. Wu Q,^# Wang H,^# An P, Tao Y, Deng J, Zhang Z, Shen Y, Chen C, Min J,* Wang F *. HJV and HFE play distinct roles in regulating hepcidin. Antioxidants & Redox Signaling, 22, 1325–1336 (2015).

30. Guo X, ^# Zhou D,^# An P,^# Wu Q, Wang H, Wu A, Mu M, Zhang D, Zhang Z, Wang H, He L, Liu Y,* Wang F *. (2013) Associations between serum hepcidin, ferritin and Hb concentrations and type 2 diabetes risks in a Han Chinese population. British Journal of Nutrition, 110, 2180–2185. (# Co-first author)

31. Mu M, Wu A, An P, Du X, Wu Q, Shen X, Wang, F^*. Black soyabean seed coat extract regulates iron metabolism by inhibiting the expression of hepcidin. British Journal of Nutrition, 111, 1181–1189 (2014).

32. Guan Y,^# An P,^# Zhang Z, Zhang F, Yu Y, Wu Q, Shi Y, Guo X, Tao Y, Wang F^*. Screening identifies the chinese medicinal plant Caulis Spatholobi as an effective HAMP expression inhibitor. The Journal of Nutrition, 143, 1061–1066 (2013). (# Co-first author)

33. An P, Wu Q, Wang H, Guan Y, Mu M, Liao Y, Zhou D, Song P, Wang C, Meng L, Man Q, Li L, Zhang J, Wang F^*. TMPRSS6, but not TF, TFR2 or BMP2 variants are associated with increased risk of iron-deficiency anemia. Human Molecular Genetics, 21, 2124–2131 (2012).

34. Zhang Z, Zhang F, Guo X, An P, Tao Y, Wang F^*. Ferroportin1 in hepatocytes and macrophages is required for the efficient mobilization of body iron stores in mice. Hepatology, 56, 961–971 (2012).

35. Sun L,^# Yu Y,^# Huang T,^# An P, Yu D, Yu Z, Li H, Sheng H, Cai L, Xue J, Jing M, Li Y,^* Lin X,^* Wang F^*. Associations between ionomic profile and metabolic abnormalities in human population. PLoS ONE, 7, e38845 (2012).

36. Gan W,^# Guan Y,^# Wu Q, An P, Zhu J, Lu L, Jing L, Yu Y, Ruan S, Xie D, Makrides M, Gibson RA, Anderson GJ, Li H,^* Lin X,^* Wang F^*. Association of TMPRSS6 polymorphisms with ferritin, hemoglobin, and type 2 diabetes risk in a Chinese Han population. The American Journal of Clinical Nutrition, 95, 626–632 (2011).

37. Zhang Z, Zhang F, An P, Guo X, Shen Y, Tao Y, Wu Q, Zhang Y, Yu Y, Ning B, Nie G, Knutson MD, Anderson GJ, Wang F^*. Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses. Blood, 118, 1912–1922 (2011).