2023.05-至今 中国农业大学，优秀人才引进，副教授

2023.01-2023.05 广州市妇女儿童医疗中心，副研究员

2019.07-2022.12 中国科学院生物物理研究所，助理研究员

2016.08-2019.06 中国科学院生物物理研究所，博士后

2011.09-2016.06 中国农业大学，理学博士

2007.09-2011.06 大连理工大学，工学学士

1. 基于生物信息学，开发高通量数据挖掘的算法，探索衰老和发育相关疾病的表观遗传学和免疫学机制

2. 通过宏基因组学方法，针对益生菌、膳食纤维等功能食品，研究其调节肠道菌群和改善宿主病理状态的功能机制

3. 基于网络爬虫、数据库技术和深度学习/人工智能方法，开发个性化膳食营养推荐系统与健康大数据平台

1. 基于网络大数据技术设计和构建菜肴膳食营养数据库，国家重点研发计划子课题，2023.12-2027.12，主持

2. 营养健康膳食推荐系统的构建及其在高血脂与高血脂人群的应用，2025.03-2026.03，校企合作横向项目，主持

3. 益生菌缓解便秘诱导抑郁共病的功能机制研究，2024.07-2025.6，校企合作横向项目，主持

4. 降血糖益生菌的筛选及功能产品开发，2024.04-2025.04，校企合作横向项目，主持

5. 热处理对发酵乳中副干酪乳杆菌代谢产物的影响，2023.11-2025.12，校企合作横向项目，主持

6. 益生菌对血脂的改善作用及机制研究，2024.09.-2025.12，校企合作横向项目，主持

7. H3.3及其分子伴侣 HIRA介导H2A.Z在基因组中置换的分子机制及其对基因转录和神经元干细胞分化调控的研究，2019.01-2021.12，国家自然科学基金青年科学基金，主持

8. 染色质可塑性动态调控的蛋白质机器及其作用机理，国家重点研发计划，2019.01-2021.12，骨干参与

一、发表文章（#为共同第一作者，*为通讯作者）

1. Jian Wang#, Yimei Ren#, Juan Chen#, Shanbin Chen#, Xiaoxia Li, Jianwen Chen, Xifan Wang, Lijun Li, Liang Zhao, Yixuan Li, Qi Zhang, Wei Xiong, Huiyuan Guo, Hao Zhang, Xiaoxu Zhang, Fuqing Wang, Yanling Hao, Jingjing He, Bing Fang, Jie Guo, Shaoyang Ge, Fazheng Ren, Liwei Zhang*, Jie Luo*, Ran Wang*, Yulong Yin*. (2025). Bifidobacterium animalis subsp. Lactis A6 alleviates comorbid constipation and depression by rebalancing tryptophan metabolism. Science Bulletin. doi: 10.1016/j.scib.2025.04.042.

2. Yiran Guan#, Ruixin Zhu#, Wen Zhao#, Langrun Wang#, You Zhao, zhong Zeng Qiuyue Jiang, Zeyang Zhu, Jiayu GouJ, Qi ZhangJie GuoJ, Keji Li, Liang Zhao, Yixuan Li, Pengjie Wang, Bing Fang, Weilian Hung, Jian He, Liwei Zhang*, Ran Wang*, Jingjing He*. (2025). Effects of Lacticaseibacillus paracasei K56 on perceived stress among pregraduate students: a double-blind, randomized, placebo-controlled trial. Frontiers in Nutrition. doi: 10.3389/fnut.2025.1544713.

3. Qixiang Zhang#, Xuyuan Zhang#, Yalan Zhu#, Panpan Sun#, Liwei Zhang, Junxiao Ma, Yong Zhang, Lingan Zeng, Xiaohua Nie, Yina Gao, Zhaolong Li, Songqing Liu, Jizhong Lou, Ang Gao*, Liguo Zhang*, Pu Gao*. (2022). Recognition of cyclic dinucleotides and folates by human SLC19A1. Nature. doi: 10.1038/s41586-022-05452-z.

4. Linnan Zhang, Jianping Ma, Xiaoyang Jin, Liwei Zhang, Mengfan Zhang, Patrick Z Li, Jingyun Li, Liguo Zhang (2022). Human IFNAR2 Mutant Generated by CRISPR/Cas9-Induced Exon Skipping Upregulates a Subset of Tonic-Like Interferon-Stimulated Genes Upon IFNβ Stimulation. J Interferon Cytokine Res. doi: 10.1089/jir.2022.0158.

5. Yang Yang#, Liwei Zhang#*, Chaoyang Xiong, Jun Chen, Li Wang, Zengqi Wen, Juan Yu, Ping Chen, Yanhui Xu, Jingji Jin, Yong Cai*, Guohong Li*. (2022). HIRA complex presets transcriptional potential through coordinating depositions of the histone variants H3.3 and H2A.Z on the poised genes in mESCs. Nucleic Acids Research. doi: 10.1093/nar/gkab1221.

6. Haizhen Long#, Liwei Zhang#, Mengjie Lv#, Zengqi Wen#，Wenhao Zhang, Xiulan Chen, Peitao Zhang, Luyuan Chang, Caiwei Jin, Xi Wang, Fuquan Yang, Ping Chen, Raphael Margueron, Haiteng Deng, Mingzhao Zhu*, Guohong Li*. (2020). H2A.Z Facilitates Licensing and Activation of Early Replication Origins. Nature. doi:  10.1038/s41586-019-1877-9.

7. Zengqi Wen*, Liwei Zhang, Haihe Ruan*, and Guohong Li*. (2020). Histone variant H2A.Z regulates nucleosome unwrapping and CTCF binding in mouse ES cells. Nucleic Acids Research. doi: 10.1093/nar/gkaa360.

8. Yongzheng Li#, Boxin Xue#, Mengling Zhang#, Liwei Zhang, Yingping Hou, Yizhi Qin, Haizhen Long, Qian Peter Su, Yao Wang, Xiaodong Guan, Yanyan Jin, Yuan Cao, Guohong Li, Yujie Sun*. (2021). Transcription-coupled structural dynamics of topologically associating domains regulate replication origin efficiency. Genome Biology. doi: 10.1186/s13059-021-02424-w.

9. Yanhui Xiao#, Wenjing Li#, Hui Yang#, Lulu Pan, Liwei Zhang, Lu Lu, Jiwei Chen, Wei Wei, Jie Ye, Jiwen Li, Guohong Li, Yong Zhang, Minjia Tan, Jianping Ding*, Jiemin Wong*. (2021). HBO1 is a versatile histone acyltransferase critical for promoter histone acylations. Nucleic Acids Research. doi: 10.1093/nar/gkab607.

10. Jiaotong Yang, Yue Liu, Hengyu Yan, Tian Tian, Qi You, Liwei Zhang, Wenying Xu, Zhen Su. (2018). PlantEAR: functional analysis platform for plant EAR motif-containing proteins. Frontiers in Genetics. doi: 10.3389/fgene.2018.00590.

11. Qi You, Wenying Xu, Kang Zhang, Liwei Zhang, Xin Yi, Dongxia Yao, Chunchao Wang, Xueyan Zhang, Xinhua Zhao, Nicholas Provart, Fuguang Li, Zhen Su. (2016). ccNET: Database of co-expression networks with functional modules for diploid and polyploid Gossypium. Nucleic Acids Research. doi:10.1093/nar/gkw910.

12. Kang Zhang, Qian Song, Qiang Wei, Chunchao Wang, Liwei Zhang, Wenying Xu, Zhen Su. (2016). Down-regulation of OsSPX1 caused semi-male sterility, resulting in reduction of grain yield in rice. Plant Biotechnology Journal. doi: 10.1111/pbi.12527.

13. Liwei Zhang#, Jinyan Guo#, Qi You, Xin Yi, Yi Ling, WenyingXu, Jinping Hua, Zhen Su*. (2015). GraP: Platform for Functional Genomics Analysis of Gossypium raimondii. Database. doi:10.1093/database/bav047.

14. Qi You, Liwei Zhang, Xin Yi, Zhenghai Zhang, Wengying Xu, and Zhen Su. (2015). SIFGD: Setaria italica Functional Genomics Database. Molecular Plant. doi:10.1016/j.molp.2015.02.001.

15. Jinyan Guo, Gongyao Shi, Liwei Zhang, Wenying Xu, Yumei Wang, Zhen Su, Jinping Hua. (2015). Transcriptome analysis reveals that distinct metabolic pathways operate in salt-tolerant and salt-sensitive upland cotton varieties subjected to salinity stress. Plant Science. doi:10.1016/j.plantsci. 2015.05.013.

16. Zhenyan Miao, Wei Xu, Daofeng Li, Xiaona Hu, Jiaxing Liu, Rongxue Zhang, Zongyong Tong, Jiangli Dong, Zhen Su, Liwei Zhang, Min Sun, Wenjie Li, Zhenglin Du, Songnian Hu, Tao Wang. (2015). De novo transcriptome analysis of Medicago falcata reveals novel insights about the mechanisms underlying abiotic stress-responsive pathway. BMC Genomics. doi:10.1186/s12864-015-2019-x.

二、科研奖项

1. 染色质结构与表观遗传调控研究集体，2022，中国科学院杰出科技成就奖

2. 口腔益生菌高校筛选及应用关键技术，2023，中国商业联合会科学技术奖

3. 精神健康乳制品的关键技术创新与产品开发，2024，中国乳制品工业协会技术进步奖

三、授权专利

1. 苏震，徐文英，魏强，王玲，刘凤霞，于静娟，赵琳娜，张力圩“OsSPX1蛋白及其编码基因在调节植物花粉育性中的应用” 专利号201210253451.7

2. 葛晓阳，李付广，苏震，徐文英，达玲玲，詹晶晶，姚冬霞，张力圩“一种亚洲棉miR172c在调控目的植物应答盐胁迫中的应用”  专利号202010149664.X

3. 葛晓阳，李付广，苏震，徐文英，达玲玲，詹晶晶，姚冬霞，张力圩“miR164a在应答亚洲棉耐盐中的应用” 专利号202010952096.7