2024.11-至今       中国农业大学营养与健康系    副教授/研究员

2022.3-2024.10   清华大学化学系                     博士后、助理研究员

2021.7-2022.2     南昌大学医学部                     副教授

2018.9-2021.6     清华大学化学系   分析化学    理学博士

2017.1-2018.8     清华大学化学系                    科研助理

2014.9-2017.1     东北大学理学院   物理化学    理学硕士

2010.9-2014.7    江西科技师范大学 应用化学   理学学士

学术兼职

中国医药生物技术协会药物分析技术分会                     委员

中国民族医药学会方药量效研究分会                            常务理事

中国中药协会大品种开发与培育专业委员会                  委员

中国分析测试协会毒物分析分会                                   委员

中国检验检测学会青委会                                             理事

北京理化分析测试技术学会青委会                                理事

《J Pharm Anal》、《Exploration》、《MedMat》   青年编委

学术奖励与荣誉

2024   中国科协党校青年科技领军人才“领航计划”

2022   国家博士后创新人才支持计划（药物分析学）

2023   北京市科协青年人才托举工程

2023   北京市科协创新争先科技工作者

2023   清华大学化学系卓越博士后

2022   清华-北大生命科学联合中心特等博士后

2018   辽宁省优秀硕士毕业论文

研究领域

主要研究方向为药物分析，微流控芯片，生命与健康分析

研究概况

以“复杂体系分析”为主要研究方向，以微流控技术和纳米技术为基础，融合药物分析与生命分析、整合药效物质分析与药理效应分析评价的战略，采用“三位一体”的策略，开展了纳米酶复杂体系体外质量分析、胞内命运分析和体内效应分析研究，取得了系列创新性研究成果：1）提出了精准控制纳米酶复杂体系合成新策略；证明了微流控通道在纳米酶复杂体系制备中的流体限域效应；建立了纳米酶复杂体系质量控制分析新方法。2）解析了纳米酶复杂体系胞内作用机制与路径；揭示了纳米酶复杂体系体内代谢时空命运；提出了“High-Entropy Nanozymes”（高熵纳米酶）的概念。3）构建了微流控器官/类器官芯片药物分析新模型；实现了药物高效率、微型化和集成化分析目标，夯实了“Pharm-Lab on a Chip”新技术。近年来发表SCI论文70余篇，在Adv. Mater., Adv. Funct. Mater., Adv. Sci., TrAC.和Anal. Chem.等国际知名期刊以第一作者和通讯作者（含共同）发表IF>10的高水平SCI论文30余篇，其中ESI高被引论文3篇，论文总被引4300余次，H指数37，授权发明专利11项。

1.      国家自然科学基金面上项目，项目编号：82574366，2026.1-2029.12，主持，在研。

2.      北京市自然科学基金重点项目课题，项目编号：L256002，2025.7-2027.7，主持，在研。

3.      企业横向菌株的功能评价研究课题，项目编号：202505423141441，2025.11-2027.11，主持，在研。

4.      中国农业大学青年研究员项目，项目编号：2024QNYJY143，2024.11-2029.11，主持，在研。

5.      国家自然科学基金青年项目，项目编号：82304442，2024.1-2026.12，主持，在研。

6.      国家重点研发计划子课题，项目编号：2023YFC3504401，2024.1-2026.12，主持，在研。

7.      国家重点研发计划子课题，项目编号：2022YFA1103403，2023.1-2027.12，主持，在研。

8.      北京市科协青年人才托举工程，项目编号：BYESS2023166，2023.1-2025.12， 主持，结题。

9.      国家博士后创新人才支持计划，项目编号：BX20220160，2022.3-2024.3，主持，结题。

10. 中国博士后科学基金面上项目，项目编号：2022M711779，2022.3-2024.3，主持，结题。

1.        Yongjian Ai*, Zhengyu Wang, Wenhao Shi, Xiaomeng Jia, Mengyang Cui, Hong-bin Sun, Fazheng Ren, Meng-Qi He*, Qionglin Liang*. Atomic-level high-entropy nanozymes enable remarkable endogenous targeted catalysis and enhancing tumor photothermal therapy, Advanced Materials, 2025, 37, 2502322.

2.        Yongjian Ai*, Meng-Qi He, Hua Sun, Wanting Hu, Xinyue Zhang, Hong-bin Sun, Qionglin Liang*. Ultra-small high-entropy alloy nanoparticles: efficient nanozyme for enhancing tumor photothermal therapy, Advanced Materials, 2023, 35, 2302335. (ESI高被引)

3.        Meng-Qi He, Yongjian Ai*, Wanting Hu, Liandi Guan, Mingyu Ding, Qionglin Liang*. Recent advances of seed-mediated growth of metal nanoparticles: from growth to applications, Advanced Materials, 2023, 35, 2211915.

4.        Yongjian Ai, Ze-Nan Hu, Xiaoping Liang*, Hong-bin Sun, Hongbo Xin*, Qionglin Liang*. Recent advances in nanozymes: from matters to bioapplications, Advanced Functional Materials, 2022, 32, 2110432. (ESI高被引)

5.        Yongjian Ai, Hua Sun, Zhuxian Gao, Chenlong Wang, Liandi Guan, Yu Wang, Yanping Wang, Huiying Zhang, Qionglin Liang*. Dual enzyme mimics based on metal-ligand cross-linking strategy for accelerating ascorbate oxidation and enhancing tumor therapy, Advanced Functional Materials, 2021, 31, 2103581.

6.        Jianghua Zhang‡, Yongjian Ai‡, Jiajing Wu, Daile Zhang, Yun Wang, Zhongmin Feng, Hong-Bin Sun*, Qionglin Liang, Ting Sun*, Yang Yang*. Nickel-catalyzed synthesis of three-dimensional edge-curled graphene for high-performance lithium-ion batteries, Advanced Functional Materials, 2020, 30, 1904645.

7.        Yongjian Ai, Zenan Hu, Lei Liu, Junjie Zhou, Yang Long, Jifan Li, Mingyu Ding, Hong-Bin Sun*, Qionglin Liang*. Magnetically hollow Pt nanocages with ultrathin walls as a highly integrated nanoreactor for catalytic transfer hydrogenation reaction, Advanced Science, 2019, 6, 1802132.

8.        Yongjian Ai*, Lili Li, Ruoxiao Xie, Pengjie Wang, Huiyuan Guo, Fazheng Ren, Meng-Qi He*, Qionglin Liang*. When microfluidics meets pharmaceutical analysis, TrAC-Trends in Analytical Chemistry, 2025, 118518.

9.        Yan-Fei Zhu, Meng-Qi He*, Cai-Shi Lin, Wei-Heng Ma, Yongjian Ai*, Jing Wang*, Qionglin Liang*. Multifunctional nanocarrier drug delivery systems: from diverse design to precise biomedical applications, Advanced Healthcare Materials, 2025, 2502178.

10.    Miao Hu, Fanghua Liu, Jun Zhang, Lin Yang, Yiting Yan, Ying Wang, Mengzhen Liu, Haofan An, Liping Zhu, Yongjian Ai*, Xue Jiang*. Integrated CRISPR/Cas12a-activated liposomal SERS amplification in microfluidic chips for ultrasensitive ampicillin detection, Biosensors and Bioelectronics, 2025, 118131.

11.    Cai-Shi Lin, Wenhao Shi, Yanfei Zhu, Weiheng Ma, Yongjian Ai*, Jing Wang*, Qionglin Liang*, Meng-Qi He*. Atomic iron-engineered dual-modal nanozyme enhances tumor-targeted chemodynamic/photothermal synergistic therapy, Nano Research, 2025, 94908256.

12.    Meng-Qi He*, Meng-Ying An, Zhenyu Wang, Cai-Shi Lin, Wenhao Shi, Hong-bin Sun, Fazheng Ren, Qionglin Liang*, Yongjian Ai*. Ultra-small medium-entropy nanozymes for targeting catalysis therapy of tumor, Chemical Engineering Journal, 2025, 526, 170863.

13.    Xinmei Xu, Yue Liu, Shufu Yu, Suet Cheung, Mengyang Cui, Yongjian Ai*, Yi Zhang*, Qionglin Liang*. Integration of heart-on-a-chip and metabolomics for understanding the toxicity-attenuating effect of ethnomedicinal processing, Phytomedicine, 2025, 145, 156985.

14.    Yiting Yan, Fanghua Liu, Zihan Liu, Lin Yang, Miao Hu, Jun Zhang, Tong Xu, Yongjian Ai*, Xue Jiang*. Ultrathin NiSe₂/Co₃Se₄ heterojunction nanosheets for electrochemical detection of foodborne formaldehyde, Food Chemistry, 2025, 495, 146292.

15.    Imamdin Chandio, Qisen Jiao, Ruiqi Li, Yongjian Ai*, Qionglin Liang*. Dual-signal electrochemical aptasensor based on high-entropy alloy nanosheets for calprotectin detection in inflammatory bowel disease, ACS Applied Materials & Interfaces, 2025, 17, 38960–38970.

16.    Cai-Shi Lin‡, Meng-Qi He‡, Meng-Ying An, Qi-Hang Zhao, Zhou-Hang Zhang, Ke-Yu Deng, Yongjian Ai*, Hong-Bo Xin*. Ultra-small copper-based multienzyme-like nanoparticles protect against hepatic ischemia-reperfusion injury through scavenging reactive oxygen species in mice, Small, 2024, 20, 2403313.

17.    Xinmei Xu‡, Suet Cheung‡, Xiaomeng Jia^, Gang Fan, Yongjian Ai*, Yi Zhang*, Qionglin Liang*. Trends in organ-on-a-chip for pharmacological analysis, TrAC-Trends in Analytical Chemistry, 2024, 180, 117905.

18.    Imamdin Chandio, Yongjian Ai*, Lei Wu, Qionglin Liang*, Recent progress in MOFs-based nanozymes for biosensing, Nano Research, 2024, 17, 39–64. (ESI高被引)

19.    Meng-Qi He, Yongjian Ai*, Wanting Hu, Xiaomeng Jia, Lei Wu, Mingyu Ding, Qionglin Liang*. Dual-functional capping agent mediated-transformation of silver nanotriangles to silver nanoclusters for dual-mode biosensing, Analytical Chemistry, 2023. 95, 6130–6137.

20.    Mengying An‡, Mengqi He‡, Caishi Lin, Yuebo Wu, Yongjian Ai*, Hongbo Xin*, Qionglin Liang*. Recent progress of nanozymes with different spatial dimensions for bioanalysis, Materials Today Nano, 2023, 22, 100330.

21.    Yongjian Ai, Hua Sun, Chenlong Wang, Wenchen Zheng, Qiang Han, Qionglin Liang*. Tunable assembly of organic-inorganic molecules into hierarchical superstructures as ligase mimics for enhance tumors photothermal therapy, Small, 2022, 18, 2105304.

22.    Yongjian Ai‡, Meng-qi He‡, Chengxian Wan, Hua Lu, Hongbo Xin*, Yitao Wang*, Qionglin Liang*, Nanoplatform-based reactive oxygen species scavengers for therapy of ischemia-reperfusion injury, Advanced Therapeutics, 2022, 5, 2200066.

23.    Yongjian Ai, Jinzhi You, Jianyi Gao, Jiaping Wang, Hong-bin Sun, Mingyu Ding, Qionglin Liang*. Multi-shell nanocomposites based multienzyme mimetics for efficient intracellular antioxidation, Nano Research, 2021, 14, 2644–2653.

24.    Yongjian Ai, Ruoxiao Xie, Jialiang Xiong, Qionglin Liang*. Microfluidics for biosynthesizing: from droplets and vesicles to artificial cells, Small, 2020, 16, 1903940.

25.    Yongjian Ai, Feng Zhang, Chenlong Wang, Ruoxiao Xie, Qionglin Liang*. Recent progress in lab-on-a-chip for pharmaceutical analysis and pharmacological/toxicological test, TrAC-Trends in Analytical Chemistry, 2019, 117, 215–230.