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师资力量

  • 姓  名:许文涛
  • 性  别:男
  • 职  称:教授
  • 所在系别:营养与健康系
  • 办公地点:中国农业大学建大校区1号楼
  • 电子邮箱:xuwentao@cau.edu.cn
个人简历

2021--至今:中国农业大学营养与健康系, 教授

2019--至今:中国农业大学“人才培育发展支持计划”青年新星A类,校级“功能核酸”青年科学家创新团队,特聘研究员;

2013-2014:美国马里兰大学,访问学者;

2006-2020:中国农业大学,任教讲师、副教授;

1997-2006:中国农业大学,工学学士、工学博士;

2019、2021年度:荣获 中国农业大学“优秀教师”荣誉称号;

2014年:荣获 第二届“师恩杯”我最喜爱的导师;

入选北京市科技新星、教育部新世纪优秀人才;

农业农村部农产品质量监督检验测试中心(北京)  副主任兼技术负责人;

农业农村部农业转基因生物安全评价(食用)重点实验室 副主任

农业农村部农产品贮运保鲜质量安全风险评估实验室(北京) 副主任;

北京理化分析测试技术学会适配体交叉技术分会 秘书长;

国际学术杂志《Journal of DNA and RNA Research》主编;《Frontiers in Bioengineering and Biotechnology》、《Toxins》、《Mini-Reviews in Organic Chemistry》编委;国内学术杂志《生物技术通报》、《生物技术进展》、《食品与营养科学》编委;

出版专著:《功能核酸生物传感器-理论篇》、《Functional Nucleic Acids Detection in Food Safety》、《Ochratoxin A: Biosynthesis, Detection and Biological Toxicity》、《食品安全典型案例解析及教程》;

主编教材:《食品安全学》、《转基因食品安全评价与检测技术》、《食品安全案例解析》、《转基因食品社会文化伦理透视》;

参与奖项:国家级教学成果奖1项、教材奖1项;中华神农奖、北京市科技进步奖、湖北省技术发明奖、河北省科技进步奖、科技兴检奖等省部级10余项;


研究方向

1.功能核酸:筛选裁剪、生物传感、纳米材料及靶向药物

2.功能食品:配方开发、作用机制、精准营养及功效评价

3.生物安全:农业生物技术及合成生物学产品分子特征及安全评价;生物毒素精准检测及精准毒理机制解析



课题项目

1.国家自然基金重大仪器专项“单细胞代谢毒理学效应超灵敏精准质谱分析装置研制”(2020-2024) 子课题主持

2.国家自然基金面上项目“基于复合纳米材料的食源性致病微生物超灵敏等温核酸生物传感器及智能定量装备的研究”(2019-2022)主持

3.国家自然基金面上项目“基于“磁三核酸-肽核酸”的食源性致病微生物条形码纸基光学传感器的研究”(2016-2019)主持

4.转基因专项“基因组编辑新型转基因动物产品安全评价技术研究”(2018-2019)主持

5.转基因专项“复合性状转基因成分检测、溯源技术及标识阈值研究     转基因专项“     (2014-2016)主持

6.转基因专项“转基因产品现场快速检测仪器设备研发”(2018-2020)主持

7.863计划“食用农产品病原菌分子检测技术开发及生物安全控制”(2012-2015)子课题主持

8.北京市科技新星“食源性致病菌新型等温PCR现场快速检测及核酸试纸条关键技术研究”(2014-2017)主持

9.  北京市科技新星交叉项目“食源性致病菌现场快速检测核酸层析试纸条系列产品的研发”(2017-2018)主持    

10.教育部新世纪人才项目“ASK1参与调控赭曲霉毒素A诱导的肾细胞毒性作用机制研究”(2014-2016)主持    


论文著作

代表性论文

1.       Jingjing Tian; Huashuo Chu; ... & Wentao Xu*; TiO2 Nanoparticle-Enhanced Linker Recombinant Strand Displacement Amplification (LRSDA) for Universal Label-Free Visual Bioassays, ACS Applied Materials & Interfaces, 2019, 11(50): 46504-46514. (封面文章)

2.       Longjiao Zhu; Miao Miao; ... & Wentao Xu*; A universal electrochemical biosensor using nick-HCR nanostructure as molecular gate of nanochannel for detecting Chromium (III)ions and microRNA, Analytical Chemistry, 2019, 91(23): 14992-14999. (封面文章)

3.       Nan Cheng; Yang Song; ... & Wentao Xu*; Yuehe Lin*; Au@Pd Nanopopcorn and Aptamer Nanoflower Assisted Lateral Flow Strip for Thermal Detection of Exosomes, Analytical Chemistry, 2019, 91(21):13986-13993. (封面文章)

4.       Yuxiang Feng#; Xiangli Shao#; ... & Wentao Xu*; Mercury nanoladders: a new method for DNA amplification, signal identification and their application in the detection of Hg (II) ions, Chemical Communications, 2018, 54(58): 8036-8039. (封面文章)

5.       Nan Cheng; Qin Wang; ... & Wentao Xu*; Yunbo Luo*; Rapid and low-cost strategy for detecting genome-editing induced deletion: A single-copy case, Analytica Chimica Acta, 2018, 1019: 111-118. (亮点文章)

6.       Zhang, Yangzi., Zhu Longjia.,  ... & Xu, W.* . Smart and Functionalized Development of Nucleic Acid‐Based Hydrogels: Assembly Strategies, Recent Advances, and Challenges. Advanced Science, 2021,2100216.

7.       Xu Wentao.;  He Wanchong; ... & Luo, Y.*, Functional Nucleic Acids‐Nanomaterials: Development, Properties, and Applications. Angewandte Chemie International Edition 2021, 60(13), 6890-6918 .

8.       Yuan Su, Huashuo Chu, ... & W Xu*,Insight into the nanomaterials enhancement mechanism of nucleic acid amplification reactions. TrAC Trends in Analytical Chemistry, 2021,116221.

9.       Mingzhang Guo, Kunlun Huang, Xu, W.*, Third Generation Whole-Cell Sensing Systems: Synthetic Biology Inside, Nanomaterial Outside. Trends in Biotechnology 2021, 39 (6), 550-559

10.    Boyang Zhang, Hongyu Li, ... & W Xu*,Single-cell transcriptomics uncovers potential marker genes of ochratoxin A–sensitive renal cells in an acute toxicity rat model. Cell Biology and Toxicology 2021, 37, 7-13.

11.    Liye Zhu; Jieyu Yuhan; ... & Wentao Xu*; Multidimensional analysis of the epigenetic alterations in toxicities induced by mycotoxins, Food and Chemical Toxicology, 2021, 153: 112251.

12.    Xiujuan Deng; Ganghua Huang; ... & Wentao Xu*; Evolution analysis of flavor-active compounds during artificial fermentation of Pu-erh tea, Food Chemistry, 2021, 357: 129783.

13.    Yanger Liu; Mingzhang Guo;... & Wentao Xu*; A gas reporting whole-cell microbial biosensor system for rapid on-site detection of mercury contamination in soils, Biosensors and Bioelectronics, 2020, 170: 112660.

14.    Ziqi Zhou; Yangzi Zhang; ... & Wentao Xu*; Ultrasensitive magnetic DNAzyme-copper nanoclusters fluorescent biosensor with triple amplification for the visual detection of E. coli O157:H7, Biosensors and Bioelectronics, 2020, 167: 112475.

15.    XinXian. Wang; Longjiao. Zhu;... & Wentao Xu*; Fluorescent functional nucleic acid: Principles, properties and applications in bioanalyzing. TrAC Trends in Analytical Chemistry, 2021, 141: 116292.

16.    Xiuyuan Xu; Yuan Su; ... & Wentao Xu*; Novel rolling circle amplification biosensors for food-borne microorganism detection, TrAC Trends in Analytical Chemistry, 2021, 141: 116293.

17.    Huan Song#; Yangzi Zhang#;... & Wentao Xu*; Label-free polygonal-plate fluorescent-hydrogel biosensor for ultrasensitive microRNA detection, Sensors and Actuators B: Chemical, 2020, 306: 127554.

18.    Boyang Zhang; Liye Zhu; ... & Wentao Xu*; An in vitro attempt at precision toxicology reveals the involvement of DNA methylation alteration in ochratoxin A-induced G0/G1 phase arrest, Epigenetics, 2020, 15(1-2): 199-214.

19.    Shuting Li; Yuan Zhang; Jingjing Tian; Wentao Xu*; Luminescent DNAzyme and universal blocking linker Super Polymerase Chain Reaction visual biosensor for the detection of Salmonella, Food Chemistry, 2020, 324: 126859.

20.    Ying Shang; Yuancong Xu; Kunlun Huang; Yunbo Luo; Wentao Xu*; Multiplex pyrosequencing quantitative detection combined with universal primer-multiplex-PCR for genetically modified organisms, Food Chemistry, 2020, 320: 126634.

21.    Kai Li; Yunbo Luo; ... & Wentao Xu*; Single Universal Primer Recombinase Polymerase Amplification-based Lateral Flow Biosensor (SUP-RPA-LFB) for Multiplex Detection of Genetically Modified Maize, Analytica Chimica Acta, 2020, 1127: 217-224.

22.    Xiangyang Li; Zaihui Du; ... & Wentao Xu*; ExoIII and TdT dependent isothermal amplification (ETDA) colorimetric biosensor for ultra-sensitive detection of Hg2+, Food Chemistry, 2020, 316:126303.

23.    Xiangli, Shao; Longjiao, Zhu; ... & Wentao, Xu*; Integration of ion-tuned oligonucleotide structural motifs and DNA-templated copper nanoclusters as a manipulable logic device, Sensors and Actuators B: Chemical, 2020, 325: 128769.

24.    Mingzhang Guo#; Jili Wang#; ... & Wentao Xu*; A test strip platform based on a whole-cell microbial biosensor for simultaneous on-site detection of total inorganic mercury pollutants in cosmetics without the need for predigestion, Biosensors and Bioelectronics, 2019, 150: 111899.

25.    Xuetong Li#; Yuan Su#; ... & Wentao Xu*; Rapid strand replacement primer thermostat visual sensor based on Bst DNA polymerase and pyrophosphatase for detecting Vibrio parahaemolyticus, Food Chemistry, 2019, 310: 125955.

26.    Huan Song; Yangzi Zhang; Ping Cheng; Xu Chen; Yunbo Luo; Wentao Xu*; A rapidly self-assembling soft-brush DNA hydrogel based on RCA products, Chemical Communications, 2019, 55(37): 5375-5378.

27.    Chao Zhang; Xiujie Zhang; ... & Wentao Xu*; Species-specific TM-LAMP and Trident-like lateral flow biosensor for on-site authenticity detection of horse and donkey meat, Sensors and Actuators B: Chemical, 2019, 301: 127039.

28.    Shuting Li; Guishan Li; ... & Wentao Xu*; The ultra-sensitive visual biosensor based on thermostatic triple step functional nucleic acid cascade amplification for detecting Zn2+, Food Chemistry, 2019, 290: 95-100.

29.    Yuancong Xu, Yujun Wei;  ... & Xu, W.*; Nucleic acid biosensor synthesis of an all-in-one universal blocking linker recombinase polymerase amplification with a peptide nucleic acid-based lateral flow device for ultrasensitive detection of food pathogens. Analytical Chemistry 2018, 90 (1), 708-715.

30.    Zhu, Longjiao.;  Shao, Xiangli.;  Luo, Y.;  Huang, K.; Xu, W.*, Two-Way Gold Nanoparticle Label-Free Sensing of Specific Sequence and Small Molecule Targets Using Switchable Concatemers. ACS Chemical Biology 2017, 12 (5), 1373-1380.


授权发明专利

1. 许文涛等; 一种铅的耐高盐核酸传感器及其应用, 2020-5-22, 中国, ZL 201711022174.8.

2. 许文涛等; 一种镉离子切割型通用隔断超快扩增可视化传感器, 2020-05-22, 中国, ZL 201810635972.6.

3. 许文涛等;  基于3D-HCR水凝胶的汞离子快速可视化检测方法, 2020-07-28, 中国, ZL 201910247622.7.

4. 许文涛等; 一种铜离子错配型通用隔断超快扩增比色传感器, 2020-07-28, 中国, ZL 201810637640.1.

5. 许文涛等;  一种基于超速PCR与功能核酸显色的定量检测方法, 2020-07-28, 中国, ZL 202010266832.3.

6. 许文涛等; 机械破碎法提取霉菌孢子DNA的方法, 2020-07-28, 中国, ZL 201710662655.9.

7. 许文涛等; 一种银的耐高盐核酸传感器及其应用, 2020-10-02, 中国, ZL 201711022203.0.

8. 许文涛等; 一种基于功能核酸的传感器及其在钠离子检测中的应用, 2020-10-02, 中国, ZL 201711022461.9.

9. 许文涛等; 一种靶向调控白色脂肪棕色化的DNA纳米花药物制备方法, 2021-05-11, 中国, ZL 2021102275282.

10. 许文涛等; 一种一体化核酸POCT检测装置及方法, 2020-11-20, 中国, ZL202010828320.1.

11. 许文涛等; 一种沙门氏菌闭管快速可视化检测方法, 2021-04-23, 中国, 202110078752X.

12. 许文涛等; 软刷子快速自组装功能核酸水凝胶的制备方法, 2021-04-23, 中国, 201910289624.2.

13. 许文涛等; 一种快速鉴定食品中驴源成分的试剂盒及其应用, 2021-04-23, 中国, 2201910289637.X.

14. 许文涛等; 一种基于微生物全细胞传感器的核酸蛋白复合物变构型重金属汞检测试纸条制备技术, 2021-06-15, 中国, 2201910289637.X.201910604609.2.

15.        许文涛等; 一种基于延伸发光引物的实时定量PCR测定Kd值的方法, 2021-09-17, 中国, 202110718435X.


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