Postdoctoral Fellow, National Institute of Biological Sciences Beijing

Ph.D. University of Saskatchewan

B.Sc. Beijing Institute of Technology

Nerve Injury and Repair Mechanisms

Nerve regeneration is much more efficient in the peripheral nervous system than in the central nervous system. Understanding the differences in PNS and CNS regeneration can help us develop strategies for improving outcomes following nerve injury. We are interested in studying the intrinsic axonal regeneration factors and identifying the role of Schwann cells during nerve injury and regeneration. Biochemical, molecular biological, histochemical, genetical and behavioral approaches are used to study key events in injured nerves and to determine the overall impact and therapeutic potential of these events.

1. Zhang, S., Y. Su, Ying, Z., D. Guo, C. Pan, J. Guo, Z. Zou, L. Wang, Z. Zhang, Z. Jiang, Z. Zhang, and X. Wang. (2019) "Rip1 Kinase Inhibitor Halts the Progression of an Immune-Induced Demyelination Disease at the Stage of Monocyte Elevation." Proc Natl Acad Sci USA 116 (12): 5675-80.

2. Ying, Z.^#, C. Pan^#, T. Shao, L. Liu, L. Li, D. Guo, S. Zhang, T. Yuan, R. Cao, Z. Jiang, S. Chen, F. Wang, and X. Wang. (2018) "Mixed Lineage Kinase Domain-Like Protein Mlkl Breaks Down Myelin Following Nerve Injury." Mol Cell 72 (3): 457-68.

3. Jiang, X., L. Li, Ying, Z., C. Pan, S. Huang, L. Li, M. Dai, B. Yan, M. Li, H. Jiang, S. Chen, Z. Zhang, and X. Wang. (2016) "A Small Molecule That Protects the Integrity of the Electron Transfer Chain Blocks the Mitochondrial Apoptotic Pathway." Mol Cell 63 (2): 229-39.

4. Ying, Z., R. Zhai, N. A. McLean, J. M. Johnston, V. Misra, and V. M. Verge. (2015) "The Unfolded Protein Response and Cholesterol Biosynthesis Link Luman/Creb3 to Regenerative Axon Growth in Sensory Neurons." J Neurosci 35 (43): 14557-70.

5. Ying, Z., V. Misra, and V. M. Verge. (2014) "Sensing Nerve Injury at the Axonal Er: Activated Luman/Creb3 Serves as a Novel Axonally Synthesized Retrograde Regeneration Signal." Proc Natl Acad Sci USA 111 (45): 16142-7.