2019 – 至今：中国农业大学生物学院  教授

2017 – 2019：清华大学结构生物学高精尖中心  博士后

2012 – 2017：清华大学生命科学学院  博士

2008 – 2012：中国农业大学生物学院  本科

以退行性疾病、免疫疾病为主的人类重大疾病相关蛋白质结构与功能的研究。

1. Zhou, R., Yang, G*., & Shi, Y. (2020). Macromolecular complex in recognition and proteolysis of amyloid precursor protein in Alzheimer’s disease. Current Opinion in Structural Biology, 61, 1-8. (*Corresponding author)

2. Zhou, R., Yang, G*., Guo, X., Zhou, Q., Lei, J., & Shi, Y. (2019). Recognition of the amyloid precursor protein by human γ-secretase. Science, 363(6428), eaaw0930. (*Co-first author)

3. Yang, G., Zhou, R., Zhou, Q., Guo, X., Yan, C., Ke, M., ... & Shi, Y. (2019). Structural basis of Notch recognition by human γ-secretase. Nature, 565(7738), 192.

4. Zhou, R., Yang, G*., & Shi, Y. (2017). Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization. Proceedings of the National Academy of Sciences, 114(48), 12731-12736. (*Co-first author)

5. Yang, G., Zhou, R., & Shi, Y. (2017). Cryo-EM structures of human γ-secretase. Current opinion in structural biology, 46, 55-64.

6. Yu, X., Yang, G*., Yan, C., Baylon, J. L., Jiang, J., Fan, H., ... & Yan, N. (2017). Dimeric structure of the uracil: proton symporter UraA provides mechanistic insights into the SLC4/23/26 transporters. Cell research, 27(8), 1020. (*Co-first author and corresponding author)

7. Sun, L., Zhou, R., Yang, G., & Shi, Y. (2017). Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase. Proceedings of the National Academy of Sciences, 114(4), E476-E485.

8. Bai, X. C., Rajendra, E., Yang, G., Shi, Y., & Scheres, S. H. (2015). Sampling the conformational space of the catalytic subunit of human γ-secretase. Elife, 4, e11182.

9. Bai, X. C., Yan, C., Yang, G*., Lu, P., Ma, D., Sun, L., ... & Shi, Y. (2015). An atomic structure of human γ-secretase. Nature, 525(7568), 212. (*Co-first author)

10. Sun, L., Zhao, L., Yang, G*., Yan, C., Zhou, R., Zhou, X., ... & Shi, Y. (2015). Structural basis of human γ-secretase assembly. Proceedings of the National Academy of Sciences, 112(19), 6003-6008. (*Co-first author)

11. Xie, T., Yan, C., Zhou, R., Zhao, Y., Sun, L., Yang, G., ... & Shi, Y. (2014). Crystal structure of the γ-secretase component nicastrin. Proceedings of the National Academy of Sciences, 111(37), 13349-13354.

12. Lu, P., Bai, X.C., Ma, D., Xie, T., Yan, C., Sun, L., Yang, G., Zhao, Y., Zhou, R., Scheres, S.H. and Shi, Y. (2014). Three-dimensional structure of human γ secretase. Nature, 512(7513), 166.