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师资力量

  • 姓  名:郝彦玲
  • 性  别:女
  • 职  称:教授
  • 所在系别:营养与健康系
  • 办公地点:中国农业大学建大校区1号楼
  • 电子邮箱:haoyl@cau.edu.cn
个人简历
研究方向

益生菌肠道适应机制的研究

乳酸菌次级代谢产物的结构及生物合成机制研究

乳酸菌发酵剂及微生态制剂的开发


课题项目

1.“十三五国家重点研发计划”乳与乳制品加工靶向物质危害控制技术集成应用示范,课题“乳与乳制品中耐药微生物的全程控制技术与应用”,课题编号:2018YFC1604303,课题负责人

2.基于苹果酸途径的副干酪乳杆菌胆盐耐受机制研究,国家自然科学基金面上项目,课题号:31972091,主持

3.长双歧杆菌BBMN68胆盐响应表面蛋白黏附机制研究,国家自然科学基金面上项目,课题号:21676294,主持

4.嗜热链球菌05-34胞外多糖的合成基因簇定向进化对发酵乳物性功能影响的研究,国家自然科学基金面上项目,课题号:21476250,主持

5.植物乳杆菌素BM-1结构鉴定及抑菌机制研究,国家自然科学基金面上项目,课题号:20176223,主持

6.保加利亚乳杆菌CAUH1酸胁迫应答机制研究,新世纪优秀人才支持计划,主持


论文著作

副主编《食品生物技术导论》和参编《现代酿造技术》两部书籍,截至2022年在国内外学术期刊累计发表论文80余篇,SCI收录第一作者或通讯作者论文40余篇。代表性文章有:

1.      Zhengyuan Zhai, Shuxins Xie, Hongxing Zhang, Huaxi Yi and Yanling Hao*. Homologous over-expression of chain length determination protein EpsC increases the molecular weight of exopolysaccharide in streptococcus thermophilus 05-34. Frontiers in Microbiology, 2021, 12:696222.

2.      Yao Xiong, Zhengyuan Zhai, Yuanqiu Lei, Bingbing Xiao, and Yanling Hao*. A Novel Major Pilin Subunit Protein FimM Is Involved in Adhesion of Bifidobacterium longum BBMN68 to Intestinal Epithelial Cells. Frontiers in Microbiology, 2020, 11:590435.

3.      Zhengyuan Zhai, Yang Yang, Hui Wang, Guohong Wang, Fazheng Ren, Zaigui Li, Yanling Hao*. Global transcriptomic analysis of Lactobacillus plantarum CAUH2 in response to hydrogen peroxide stress. Food Microbiology, 2020, 87:103389.

4.      Guohong Wang, Jiaxi Li, Shuxin Xie, Zhengyuan Zhai, and Yanling Hao*.The N-terminal domain of rhamnosyltransferase EpsF influences exopolysaccharide chain length determination in Streptococcus thermophilus 05-34. Peer J, 2020, 8:e8524.

5.      Guohong Wang, Zhengyuan Zhai, Fazheng Ren, Zaigui Li, Bing Zhang and Yanling Hao*.Combined transcriptomic and proteomic analysis of the response to bile stress in a centenarian-originated probiotic Lactobacillus salivarius Ren. Food Research International, 2020, 137:109331.

6.      Qi Xu, Zhengyuan Zhai, Haoran An, Yang Yang, Jia Yin, Guohong Wang, Fazheng Ren and Yanling Hao*. The MarR Family Regulator BmrR Is Involved in Bile Tolerance of Biodobacterium longum BBMN68 via Controling the Expression of an ABC Transporter. Appl. Environ. Microbiol., 2019, 85.3: e02453-18.

7.      Xiayin Ma, Guohong Wang, Zhengyuan Zhai, Pengyu Zhou and Yanling Hao*. Global Transcriptomic Analysis and Function Identification of Malolactic Enzyme Pathway of Lactobacillus paracasei L9 in Response to Bile Stress. Frontiers in Microbiology, 2018, 9:1978-1989.

8.      Pengyu Zhou, Zhengyuan Zhai, Yao Xiong, Peihua Ma and Yanling Hao*. Characterization of a Cryptic Rolling-Circle Replication Plasmid pMK8 from Enterococcus durans 1–8. Current Microbiology, 2018, 75:1198–1205.

9.      Yang Yang, Jia Yin, Jie Liu, Qi Xu, Tian Lan, Fazheng Ren and Yanling Hao*. The Copper Homeostasis Transcription Factor CopR Is Involved in H2O2 Stress in Lactobacillus plantarum CAUH2. Frontiers in Microbiology, 2017, 8:2015-2025.

10.   Dan Li, Jiaxi Li, Feng Zhao, Guohong Wang, Qianqian Qin and Yanling Hao*. The influence of fermentation condition on production and molecular mass of EPS produced by Streptococcus thermophilus 05-34 in milk-based medium. Food Chemistry. 2016, 367-372.

11.   Wanli Zhou, Guohong Wang, Chunmei Wang, Fazheng Ren, Yanling Hao*. Both IIC and IID Components of Mannose Phosphotransferase System Are Involved in the Specific Recognition between Immunity Protein PedB and Bacteriocin-Receptor Complex. PLOS ONE, 2016, 11(10) :e0164973.

12.   Haoran An, François P. Douillard, Guohong Wang, Zhengyuan Zhai, Jin Yang, Shuhui Song, Jianyun Cui, Fazheng Ren, Yunbo Luo, Bing Zhang and Yanling Hao*. Integrated transcriptomic and proteomic analysis of the bile stress response in a centenarian-originated probiotic Bifidobacterium longum BBMN68. Molecular & Cellular Proteomics. 2014.13(10):2558-2572.

13.   Zhao F, Wang Y, An H, Hao Y*, Hu X and Liao X*. New Insights into the Formation of Viable but Nonculturable Escherichia coli O157:H7 Induced by High-Pressure CO2.MBio, 2016 Aug 30;7 (4). pii: e00961-16. doi: 10.1128/mBio.00961-16.

14.   Zhengyuan Zhai, François P. Douillard, Haoran An, Guohong Wang, Xinghua Guo, Yunbo Luo and Yanling Hao*. Proteomic characterization of the acid tolerance response in Lactobacillus delbrueckii subsp. bulgaricus CAUH1 and functional identification of a novel acid stress-related transcriptional regulator Ldb0677. Environmental Microbiology. 2014, 16 (6), 1524–1537.

15.   Zhengyuan Zhai, Haoran An, Guohong Wang, Yunbo Luo and Yanling Hao*. Functional role of pyruvate kinase from Lactobacillus bulgaricus in acid tolerance and identification of its transcription factor by bacterial one-hybrid. Scientific Reports. 2015, 19(5): 17024.doi:10.1038/srep 17024.


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