2023.6-至今   中国农业大学营养与健康系，优秀人才引进，副教授

2021.9-2023.5 中国中医科学院青蒿素研究中心，助理研究员

2017.9-2021.8 北京大学化学与分子工程学院，博士后研究

2010.9-2017.7 中国农业大学生物学院，博士

2006.9-2010.7 华中农业大学植物科技学院，本科

1. 化学生物学解析天然产物的蛋白靶点及作用机制

2. 开发高活性抗衰老因子

3. 开发功能性食品

1. 奶水牛智能化饲喂与常见疾病防治关键技术研究及示范，380万，十四五国家重点研发计划，课题负责人

2. DHA在奶牛体内高效转化及牛奶DHA稳态，200万，横向，项目负责人

3. 缓解便秘原料组合开发及功能评价，50万，省部级，项目负责人

4. 绿色食品（绿色优质农产品）营养与健康综合评价，30万，横向，项目负责人

科研奖励：

1. 生物强化DHA乳产业化关键技术开发和应用，2024年中国乳制品工业协会技术进步奖特等奖，排名第一（1/10）

2. 富硒微生物资源利用及富硒饲料资源的开发与应用，2024年中国商业联合会技术进步奖特等奖，排名第二（2/11）

1. Zhu Y#, Wang L#, Li J#, Zhao Y, Yu X, Deng X, Liu J, Yang F, Zhang Y, Yu J, Lai L, Wang C, Li Z*, Wang L* and Luo T *. (2024) (−)-Vinigrol Targets PDI-ADAM17 Module to Induce TNFR1 Shedding and Ameliorate Rheumatoid Arthritis in Mice. Cell Chem Biol. 31, 1-13.

2. He X#, Wang C#, Zhang Q#, Yang T, Guo Q, Wang Y, Guo J, Wang P, Zhang J, Tang H*, Zhu Y* and Wang J*. (2024) Identifying ENO1 as a protein target of chlorogenic acid to inhibit cellular senescence and prevent skin photoaging in mice. Aging cell. e14433.

3. Jin W#, Zhang W#, Tang H#, Wang P, Zhang Y, Liu S, Qiu J, Chen H, Wang L, Wang R, Sun Y, Liu P, Tang H* and Zhu Y*. (2024) Microplastics exposure causes the senescence of human lung epithelial cells and mouse lungs by inducing ROS signaling. Environ Int. 185:108489.

4. Wu W, Guo X, Qu T, Huang Y, Tao J, He J, Wang X, Luo J, An P, Zhu Y*, Sun Y* and Luo Y*. (2024) The Combination of Lactoferrin and Creatine Ameliorates Muscle Decay in a Sarcopenia Murine Model. Nutrients. 16:1958.

5. Wan S, Wu W, Zhang Y, He J, Wang X, An P, Luo J*, Zhu Y*, Luo Y*. (2024) Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis. Nutrients. 16(14):2213.

6. Zhang Q#, Zhang Y#, Wang C#, Tang H, Ma A, Gao P, Shi Q, Wang G, Shen S, Zhang J, Xia F, Zhu Y* and Wang J*. (2024) Gambogic acid exhibits promising anticancer activity by inhibiting the pentose phosphate pathway in lung cancer mouse model. Phytomedicine. 129:155657.

7. Cai Y#, Zhou H#, Zhu Y#, Sun Q, Ji Y, Xue A, Wang Y, Chen W, Yu X, Wang L, Chen H, Li C, Luo T* & Deng H*. (2020). Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice. Cell Res. 30(7), 574–589.  

Sanofi-Cell Research outstanding paper award of 2020

8. Lu S#, Zhao J#, Dong J#, Liu H#, Zhu, Y#, Li H#, Liu L, Yang Y, Sun S, Song Y, Zhao Y, She R, Luo T, Deng H*, & Peng X*. (2020). Effective treatment of SARS-CoV-2-infected rhesus macaques by attenuating inflammation. Cell Res. 31(2), 229-232.

9. Zhu Y#, Zhang Y#, Zhang Q, Ma A, Zhang Y, Wang C, Tang H, Gao P, Guo Q, Xia F, Tang H*, Xu C*, Wang J*. (2022) Gambogic acid suppresses the pentose phosphate pathway by covalently inhibiting 6PGD protein in cancer cells. Chem Commun (Camb). 58(64):9030-9033.

10. Zhang Y#, Zhang Q#, Chu Z#, Chen L#, Chen J, Yang Y, Tang H, Cheng G, Ma A, Zhang Y, Wang C, Gao P, Xia F, Guo Q, Shi Q, Han G*, Wang J* and Zhu Y*. (2022) Oridonin acts as a novel senolytics by targeting Glutathione S-Transferases to activate ROS-p38 signaling axis in senescent cells. Chem Commun (Camb). 58(95):13250-13253.

11. Tang H#, Zhang Y#, Yang T, Wang C, Zhu Y, Qiu L, Liu J, Song Y, Zhou L, Zhang J, Wong YK, Liu Y, Xu C*, Wang H, Wang J*. (2023) Cholesterol modulates the physiological response to nanoparticles by changing the composition of protein corona. Nat Nanotechnol. 18(9):1067-1077.

12. Deng J, Kong L, Zhu Y, Pei D, Chen X, Wang Y, Qi J, Song C, Yang S, Gong Z. (2022) BAK1 plays contrasting roles in regulating abscisic acid-induced stomatal closure and abscisic acid-inhibited primary root growth in Arabidopsis. J Integr Plant Biol. 64(6):1264-1280.

13. Li J#, Jin J#, Li S#, Zhong Y, Jin Y, Zhang X, Xia B, Zhu Y, Guo R, Sun X, Guo J, Hu F, Xiao W, Huang F, Ye H, Li R, Zhou Y, Xiang X, Yao H, Yan Q, Su L, Wu L, Luo T, Liu Y, Guo X, Qin J, Qi H, He J*, Wang J*, Li Z*. (2022) Tonsillar Microbiome-Derived Lantibiotics Induce Structural Changes of IL-6 and IL-21 Receptors and Modulate Host Immunity. Adv Sci (Weinh). 9(30):e2202706.

14. Tang H#, Yang T#, Chen L#, Zhang Y, Zhu Y, Wang C, Liu D, Guo Q, Cheng G, Xia F, Zhong T* and Wang J*. (2023) Surface chemistry of graphene tailoring the activity of digestive enzymes by modulating interfacial molecular interactions. J Colloid Interface Sci. 630:179-192.

15. Qiu L, Zhang Y, Wei G, Wang C, Zhu Y, Yang T, Chu Z, Gao P, Cheng G, Ma A, Kwan Wong Y, Zhang J, Xu C, Wang J, Tang H. (2023) How eluents define proteomic fingerprinting of protein corona on nanoparticles. J Colloid Interface Sci. 648:497-510.

16. Yang T#, Liu D#, Li Y, Zhang Y, Zhu Y, Zhang J, Wang C, Zhang S, Wong YK, Luo P, Guo Q, Xia F, Zhong T*, Tang H*, Wang J*. (2023) Chemoproteomics reveals Sofalcone inhibits the inflammatory response of Caco-2 cells by covalently targeting HMGB1. Chem Commun (Camb). 59(58):8981-8984.

17. Gao P#, Chen J#, Sun P#, Wang J#, Tang H#, Xia F, Gu L, Zhang H, Wang C, Wong Y, Zhu Y, Xu C*, Wang J*. (2023) Chemical proteomic profiling with photoaffinity labeling strategy identifies antimalarial targets of artemisinin. Chinese Chem Lett. 34(12), 108296.

18. Wang Q, Huang Y, Li Y, Zhang L, Tang H, Zhang J, Cheng G, Zhao M, Lu T, Zhang Q, Luo P, Zhu Y, Xia F, Zhang Y, Liu D, Wang C, Li H, Qiu C, Wang J, Guo Q. (2022) Glycyrrhizic Acid Mitigates Tripterygium-Glycoside-Tablet-Induced Acute Liver Injury via PKM2 Regulated Oxidative Stress. Metabolites. 12(11):1128.