2023.6-至今   中国农业大学营养与健康系，优秀人才引进，副教授

2021.9-2023.5 中国中医科学院青蒿素研究中心，助理研究员

2017.9-2021.8 北京大学化学与分子工程学院，博士后研究

2010.9-2017.7 中国农业大学生物学院，博士

2006.9-2010.7 华中农业大学植物科技学院，本科

1. 化学生物学解析天然产物的蛋白靶点及作用机制

2. 开发高活性抗衰老因子

1. 内蒙古伊利实业集团股份有限公司横向项目，DHA在奶牛体内高效转化及牛奶DHA稳态，200万，依托中国农业大学，主持

2. 国家乳业技术创新中心省级项目，缓解便秘原料组合开发及功能评价，50万，依托中国农业大学，主持

3. 青蒿素研究中心基本科研业务费，双氢青蒿素通过抑制PI3K/AKT/mTOR信号通路治疗银屑病的机制研究，8万，依托中国中医科学院，主持

4. 国家自然科学基金，(-)-Vinigrol的不对称全合成、分子探针的制备及其作用机制研究，66万，项目批准号21977002，依托北京大学，主要参与人

5. 国家自然科学基金，化学小分子治疗新冠病毒引发的过度炎症及损伤的临床前研究，200万，项目批准号22040102，依托北京大学，主要参与人

1. Zhu Y#, Wang L#, Li J#, Zhao Y, Yu X, Deng X, Liu J, Yang F, Zhang Y, Yu J, Lai L, Wang C, Li Z*, Wang L* and Luo T *. (2024) Photoaffinity Labeling Coupled with Proteomics Identify PDI-ADAM17 Module is Targeted by (−)-Vinigrol to Induce TNFR1 Shedding and Ameliorate Rheumatoid Arthritis in Mice. Cell Chem Biol. 31, 1-13.

2. Jin W#, Zhang W#, Tang H#, Wang P, Zhang Y, Liu S, Qiu J, Chen H, Wang L, Wang R, Sun Y, Liu P, Tang H* and Zhu Y*. Microplastics exposure causes the senescence of human lung epithelial cells and mouse lungs by inducing ROS signaling (2024). Environ Int. 185:108489.

3. Zhu Y#, Zhang Y#, Zhang Q, Ma A, Zhang Y, Wang C, Tang H, Gao P, Guo Q, Xia F, Tang H*, Xu C*, Wang J*. (2022) Gambogic acid suppresses the pentose phosphate pathway by covalently inhibiting 6PGD protein in cancer cells. Chem Commun (Camb). 58(64):9030-9033.

4. Zhang Y#, Zhang Q#, Chu Z#, Chen L#, Chen J, Yang Y, Tang H, Cheng G, Ma A, Zhang Y, Wang C, Gao P, Xia F, Guo Q, Shi Q, Han G*, Wang J* and Zhu Y*. (2022) Oridonin acts as a novel senolytics by targeting Glutathione S-Transferases to activate ROS-p38 signaling axis in senescent cells. Chem Commun (Camb). 58(95):13250-13253.

5. Cai Y #, Zhou H #, Zhu Y #, Sun Q, Ji Y, Xue A, Wang Y, Chen W, Yu X, Wang L, Chen H, Li C, Luo T* & Deng H*. (2020). Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice. Cell Res. 30(7):574–589.

该论文获得赛诺菲-Cell Research 2020 年度杰出论文奖。

6. Lu S #, Zhao J #, Dong J #, Liu H #, Zhu, Y #, Li H #, Liu L, Yang Y, Sun S, Song Y, Zhao Y, She R, Luo T, Deng H*, & Peng X*. (2020). Effective treatment of SARS-CoV-2-infected rhesus macaques by attenuating inflammation. Cell Res. 31(2):229-232.

7. Tang H#, Zhang Y#, Yang T, Wang C, Zhu Y, Qiu L, Liu J, Song Y, Zhou L, Zhang J, Wong YK, Liu Y, Xu C*, Wang H, Wang J*. (2023) Cholesterol modulates the physiological response to nanoparticles by changing the composition of protein corona. Nat Nanotechnol. 18(9):1067-1077.

8. Deng J, Kong L, Zhu Y, Pei D, Chen X, Wang Y, Qi J, Song C, Yang S, Gong Z. (2022) BAK1 plays contrasting roles in regulating abscisic acid-induced stomatal closure and abscisic acid-inhibited primary root growth in Arabidopsis. J Integr Plant Biol. 64(6):1264-1280.

9. Li J#, Jin J#, Li S#, Zhong Y, Jin Y, Zhang X, Xia B, Zhu Y, Guo R, Sun X, Guo J, Hu F, Xiao W, Huang F, Ye H, Li R, Zhou Y, Xiang X, Yao H, Yan Q, Su L, Wu L, Luo T, Liu Y, Guo X, Qin J, Qi H, He J*, Wang J*, Li Z*. (2022) Tonsillar Microbiome-Derived Lantibiotics Induce Structural Changes of IL-6 and IL-21 Receptors and Modulate Host Immunity. Adv Sci (Weinh). 9(30):e2202706.

10. Tang H#, Yang T#, Chen L#, Zhang Y, Zhu Y, Wang C, Liu D, Guo Q, Cheng G, Xia F, Zhong T* and Wang J*. (2023) Surface chemistry of graphene tailoring the activity of digestive enzymes by modulating interfacial molecular interactions. J Colloid Interface Sci. 630:179-192.

11. Qiu L, Zhang Y, Wei G, Wang C, Zhu Y, Yang T, Chu Z, Gao P, Cheng G, Ma A, Kwan Wong Y, Zhang J, Xu C, Wang J, Tang H. (2023) How eluents define proteomic fingerprinting of protein corona on nanoparticles. J Colloid Interface Sci. 648:497-510.

12. Yang T#, Liu D#, Li Y, Zhang Y, Zhu Y, Zhang J, Wang C, Zhang S, Wong YK, Luo P, Guo Q, Xia F, Zhong T*, Tang H*, Wang J*. (2023) Chemoproteomics reveals Sofalcone inhibits the inflammatory response of Caco-2 cells by covalently targeting HMGB1. Chem Commun (Camb). 59(58):8981-8984.

13. Gao P#, Chen J#, Sun P#, Wang J#, Tang H#, Xia F, Gu L, Zhang H, Wang C, Wong Y, Zhu Y, Xu C*, Wang J*. (2023) Chemical proteomic profiling with photoaffinity labeling strategy identifies antimalarial targets of artemisinin. Chinese Chem Lett. 34(12), 108296.

14. Wang Q, Huang Y, Li Y, Zhang L, Tang H, Zhang J, Cheng G, Zhao M, Lu T, Zhang Q, Luo P, Zhu Y, Xia F, Zhang Y, Liu D, Wang C, Li H, Qiu C, Wang J, Guo Q. (2022) Glycyrrhizic Acid Mitigates Tripterygium-Glycoside-Tablet-Induced Acute Liver Injury via PKM2 Regulated Oxidative Stress. Metabolites. 12(11):1128.