2025年-至今，中国农业大学，教授

2021-2025年，北京大学，博士后

2015-2021年，北京大学，博士

2011-2015年，中国农业大学，学士

1. 营养物质跨膜转运的结构机制

2. 营养物质感知和信号转导的结构机制

1. 中国农业大学杰出人才引进启动项目，主持

2. 国家自然科学基金青年科学基金项目，主持

*为共同第一作者，#为通讯作者

1. Kang, Y., and Chen, L.# (2023). Structural basis for the binding of DNP and purine nucleotides onto UCP1. Nature 620, 226-231.

2. Kang, Y.*, Liu, R.*, Wu, J.X., and Chen, L.# (2019). Structural insights into the mechanism of human soluble guanylate cyclase. Nature 574, 206-210.

3. Kang, Y., and Chen, L.# (2022). Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complex. Nat Commun 13, 2639.

4. Kang, Y., Wu, J.X., and Chen, L.# (2020). Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex. Nat Commun 11, 6199.

5. Liu, R.*, Kang, Y.*, and Chen, L.# (2021). Activation mechanism of human soluble guanylate cyclase by stimulators and activators. Nat Commun 12, 5492.

6. He, X.*, Kang, Y.*, and Chen, L.# (2022). Identificaiton of ASPDH as a novel NAADP-binding protein. Biochem Biophys Res Commun 621, 168-175.

7. He, X., Kang, Y., Tao, W., Xu, J., Liu, X., and Chen, L.# (2025). Structure of small HBV surface antigen reveals mechanism of dimer formation. Cell Discov 11, 6.

8. Liu, R., Kang, Y., and Chen, L.# (2023). NO binds to the distal site of haem in the fully activated soluble guanylate cyclase. Nitric Oxide 134-135, 17-22.

9. Guo, W., Tang, Q., Wei, M., Kang, Y., Wu, J. X., and Chen, L.# (2022). Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites. Neuron 110, 1023-1035.

10. Song, K.*, Wei, M.*, Guo, W., Quan, L., Kang, Y., Wu, J. X., and Chen, L.# (2021). Structural basis for human TRPC5 channel inhibition by two distinct inhibitors. Elife 10.

11. Huang, D.*, Xu, B.*, Liu, L.*, Wu, L., Zhu, Y., Ghanbarpour, A., Wang, Y., Chen, F. J., Lyu, J., Hu, Y., Kang, Y., Zhou, W., Wang, X., Ding, W., Li, X., Jiang, Z., Chen, J., Zhang, X., Zhou, H., Li, J. Z., Guo, C., Zheng, W., Zhang, X., Li, P., Melia, T., Reinisch, K., and Chen, X. W.# (2021). TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis. Cell Metab 33, 1655-1670.

12. Guan, C., Niu, Y., Chen, S. C., Kang, Y., Wu, J. X., Nishi, K., Chang, C. C. Y., Chang, T. Y., Luo, T., and Chen, L.# (2020). Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor. Nat Commun 11, 2478.

13. Ding, D.*, Wang, M.*, Wu, J. X.*, Kang, Y., and Chen, L.# (2019). The structural basis for the binding of repaglinide to the pancreatic KATP channel. Cell Rep 27 1848-1857.

14. Zhang, M., Wang, D., Kang, Y., Wu, J. X., Yao, F., Pan, C., Yan, Z.#, Song, C.#, and Chen, L.# (2018). Structure of the mechanosensitive OSCA channel. Nat Struct Mol Biol 25, 850-858.

15. Wu, J. X., Ding, D., Wang, M., Kang, Y., Zeng, X., and Chen, L.# (2018). Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell 9, 553-567.